Increased pulsatility index supports diagnosis of vascular parkinsonism versus idiopathic Parkinson's disease.

Data de publicació: 29/12/2017 Data Ahead of Print: 29/12/2017

Autors de IIS La Fe

María Isabel Torres Cuevas

Autor
Juan Francisco Vázquez Costa

Autor
Aida Lago Martín

Autor

Autors aliens a IIS La Fe

Caba LM
Ferrairó JIT
Muñoz RB

Grups d'Investigació

Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Investigador Principal

Pilar Medina Badenes
Patología Neuromuscular y Ataxias

Investigador Principal

Teresa Sevilla Mantecón
Perinatología

Leader

Máximo Vento Torres

Abstract

INTRODUCTION: The diagnosis of vascular parkinsonism (VP) is based on a series of clinical criteria and neuroimaging findings. An increase in transcranial Doppler ultrasonography pulsatility index (PI) has been described as a frequent finding in patients with VP. We aimed to confirm this association and to determine the PI value with the highest sensitivity and specificity for diagnosis of VP. METHOD: PI was determined in all patients admitted to Hospital Universitari i Politecnic La Fe due to parkinsonism between January 2012 and June 2016. We assessed the probability of having VP based on PI values in patients with a definite diagnosis of either VP or idiopathic Parkinson's disease (IPD). A ROC curve was created to determine the PI value with the highest sensitivity and specificity. RESULTS: We assessed a total of 146 patients with suspected parkinsonism; 54 (37%) were diagnosed with IPD and 15 (10%) with VP. Patients with VP were significantly older than those with IPD (mean age of 79 vs 68.5, P=.00144) and had a higher PI (median of 1.29 [IQR: 1.09-1.38] vs 0.96 [IQR: 0.89-1.16], P=.01328). In our sample, a PI of 1.09 conferred 84% sensitivity and 70% specificity. CONCLUSIONS: In our series, the PI was significantly higher in patients with VP than in those with IPD. We therefore support the use of transcranial Doppler ultrasonography for the initial assessment of elderly patients with akinetic-rigid syndrome.

Dades de la publicació

ISSN/ISSNe:: 0213-4853, 1578-1968
Tipus:: Article
Pàgines:: 563-567
DOI:: 10.1016/j.nrl.2017.10.008
PubMed:: 29291907
Factor d'Impacte:: 0,534 SCImago ℠
Quartil:: Q2 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Caba LM:: Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, España
Ferrairó JIT:: Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, España
Torres IM:: Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, España
Costa JFV:: Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, España
Muñoz RB:: Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, España
Martin AL:: Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, España

Keywords

Doppler; Doppler transcraneal; Enfermedad de Parkinson; Parkinson's disease; Parkinsonismo vascular; Pulsatility index; Transcranial doppler; Vascular; Vascular parkinsonism; Indice de pulsatilidad

Campos d'Estudi

Projectes associats

INVESTIGACION EN RED DE LAS ENFERMEDADES NEUROLOGICAS

Investigador Principal: JUAN JESÚS VÍLCHEZ PADILLA

C03/06 . INSTITUTO DE SALUD CARLOS III . 2003

AVANCES EN EL ESTUDIO DE LA REACTIVIDAD PLAQUETARIA Y SU INTERACCION CON LOS ERITROCITOS: BASES MOLECUALRES Y APLICABILIDAD CLINICO-FARMACOLOGICA

Investigador Principal: JUANA VALLES GINER

PI03/0270 . INSTITUTO DE SALUD CARLOS III . 2004

RED DE INVESTIGACION (RENEVAS)

Investigador Principal: ENRIQUE ALBORCH DOMÍNGUEZ

RD06/0026/0006 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA DE SANTIAGO DE COMPOSTELA (FIDIS); FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2006