Portal de investigación
Antibiotic resistance and population structure of cystic fibrosis Pseudomonas aeruginosa isolates from a Spanish multi-centre study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- López-Causapé C
- de Dios-Caballero J
- Cobo M
- Escribano A
- Asensio Ó
- Oliver A
- Del Campo R
- Asensio O
- Martínez MT
- Cols M
- Vázquez C
- Baranda F
- Girón R
- Delgado I
- de Miguel MÁ
- Oliva C
- Prados MC
- Barrio MI
- de Gracia J
- Álvarez A
- Escribano A
- Castillo S
- Figuerola J
- Togores B
- Oliver A
- de Dios Caballero J
- Tato M
- Máiz L
- Suárez L
Grupos
Abstract
The first Spanish multi-centre study on the microbiology of cystic fibrosis (CF) was conducted from 2013 to 2014. The study involved 24 CF units from 17 hospitals, and recruited 341 patients. The aim of this study was to characterise Pseudomonas aeruginosa isolates, 79 of which were recovered from 75 (22%) patients. The study determined the population structure, antibiotic susceptibility profile and genetic background of the strains. Fifty-five percent of the isolates were multi-drug-resistant, and 16% were extensively drug-resistant. Defective mutS and mutL genes were observed in mutator isolates (15.2%). Considerable genetic diversity was observed by pulsed-field gel electrophoresis (70 patterns) and multi-locus sequence typing (72 sequence types). International epidemic clones were not detected. Fifty-one new and 14 previously described array tube (AT) genotypes were detected by AT technology. This study found a genetically unrelated and highly diverse CF P. aeruginosa population in Spain, not represented by the epidemic clones widely distributed across Europe, with multiple combinations of virulence factors and high antimicrobial resistance rates (except for colistin). (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0924-8579, 1872-7913
- Tipo:
- Article
- Páginas:
- 334-341
- PubMed:
- 28735882
- Factor de Impacto:
- 1,699 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
International Journal of Antimicrobial Agents ELSEVIER
Citas Recibidas en Web of Science: 24
Documentos
- No hay documentos
Filiaciones
Keywords
- Antibiotic resistance; Virulence; Multi-locus sequence typing (MLST); Array tube; Cystic fibrosis; Pseucforrumus aeruginosa
Campos de Estudio
Cita
López C,de Dios J,Cobo M,Escribano A,Asensio Ó,Oliver A,Del Campo R,CANTÓN R,SOLÉ A,CORTELL I,Asensio O,GARCÍA G,Martínez MT,Cols M,SALCEDO A,Vázquez C,Baranda F,Girón R,QUINTANA E,Delgado I,de Miguel MÁ,GARCÍA M,Oliva C,Prados MC,Barrio MI,PASTOR MD,OLVEIRA C,de Gracia J,Álvarez A,Escribano A,Castillo S,Figuerola J,Togores B,Oliver A,LÓPEZ C,de Dios J,Tato M,Máiz L,Suárez L. Antibiotic resistance and population structure of cystic fibrosis Pseudomonas aeruginosa isolates from a Spanish multi-centre study. Int. J. Antimicrob. Agents. 2017. 50. (3):p. 334-341. IF:4,253. (1).