A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.

Autores de IIS La Fe

• Esperanza Such Taboada

  Autor

• José Vicente Cervera Zamora

  Autor

• Ana Belen Valencia Martinez

  Autor

• Eva Barragán González

  Autor

• Maria Amparo Ibañez Company

  Autor

• Irene Luna Del Valle

  Autor

• Oscar Fuster Lluch

  Autor

• María Luz Perez Sirvent

  Autor

• María Leonor Senent Peris

  Autor

• Amparo Sempere Talens

  Autor

• Jesus Antonio Martinez Dominguez

  Autor

• Guillermo Martin Aragones

  Autor

• Miguel Ángel Sanz Alonso

  Autor

Grupos

• Hematología y Hemoterapia

Abstract

Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.