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  3. ESTUDIO ALEATORIZADO, DOBLE-CIEGO, CONTROLADO CON PLACEBO PARA EVALUAR LA EFICACIA Y SEGURIDAD DE ROMIPLOSTIM EN EL TRATAMIENTO DE LA TROMBOCITOPENIA EN PACIENTES CON SINDROME MIELODISPLASICO (SMD) DE RIESGO BAJO O INTERMEDIO-1.

ESTUDIO ALEATORIZADO, DOBLE-CIEGO, CONTROLADO CON PLACEBO PARA EVALUAR LA EFICACIA Y SEGURIDAD DE ROMIPLOSTIM EN EL TRATAMIENTO DE LA TROMBOCITOPENIA EN PACIENTES CON SINDROME MIELODISPLASICO (SMD) DE RIESGO BAJO O INTERMEDIO-1.

Datos básicos

Código:
20060198
Protocolo:
20060198
EUDRACT:
2007-007258-75
NCT:
Centro:
HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
Dotación:
Año de incio:
2008
Año de finalización:
2011
ENSAYO CLÍNICO INTERNACIONAL

Documentos

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Participantes

Grupos

Resultados del Ensayo Clínico

Role of de-escalation and combination therapy strategies in the management of invasive fungal infection: A multidisciplinary point of view.

Zaragoza R; (...); Romá E

Capítulo de un Libro. 2010


A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.

Such E; (...); Sanz MA

Article. 10.1182/blood-2010-06-291658. 2011


Absence of mutations in the tyrosine kinase and juxtamembrane domains of C-FMS gene in chronic myelomonocytic leukemia (CMML).

Such, Esperanza; (...); Sanz, Guillermo F

Article. 10.1016/j.leukres.2009.03.018. 2009


Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy

Cervera, Jose; (...); Sanz, Miguel A.

Article. 10.3324/haematol.2009.013243. 2010

  • Open Access.

Análisis de minimización de costes de darbepoetina alfa frente a epoetina alfa en pacientes con insuficiencia renal crónica sometidos a hemodiálisis.

Cuesta Grueso C; (...); Romá Sánchez E

Abstract of Published Item. 10.1016/j.farma.2009.12.001. 2010

  • Open Access.

Analysis of EQ-5D scores from two phase 3 clinical trials of romiplostim in the treatment of immune thrombocytopenia (ITP).

Sanz MA; (...); Isitt JJ

Article. 10.1016/j.jval.2010.10.017. 2011


ANTIFUNGAL SUSCEPTIBILITY OF CANDIDA PARAPSILOSIS AND CANDIDA ALBICANS BLOODSTREAM ISOLATES TO AMPHOTERICIN B DETERMINED BY FLOW CYTOMETRY METHODOLOGY

Cordon, Lourdes; (...); Peman, Javier

Article. 2010


Assessment of the effectiveness and safety of natalizumab for treating relapsing-remitting multiple sclerosis.

Fernández-Megía MJ; (...); Poveda-Andrés JL

Article. 10.1016/j.farma.2010.02.003. 2011

  • Open Access.

Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy without intrathecal prophylaxis

Montesinos, Pau; (...); Sanz, Miguel A.

Article. 10.3324/haematol.2009.007872. 2009

  • Open Access.

Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens

Montesinos, Pau; (...); Sanz, Miguel A.

Article. 10.1182/blood-2010-04-277434. 2011


Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia.

Valencia A; (...); Sanz MA

Article. 10.1155/2009/187125. 2009


Cord blood transplantation from unrelated donors in adults with high-risk acute myeloid leukemia.

Sanz J; (...); Sanz GF

Article. 10.1016/j.bbmt.2009.09.001. 2010


Chronic Myelomonocytic Leukemia (CMML) with More Than 15% of Ring Sideroblasts in Bone Marrow: An Overlapping Disorder Between CMML and Refractory Anemia with Ring Sideroblasts

Such, Esperanza; (...); Sanz, Guillermo

Article. 2009


Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

Montesinos, Pau; (...); Sanz, Miguel A.

Article. 10.1182/blood-2008-07-168617. 2009

  • Open Access.

Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group

Tallman, Martin S.; (...); Sanz, Miguel A.

Article. 10.1182/blood-2010-06-288613. 2010


Efficacy and safety of rituximab in adult patients with idiopathic relapsing or refractory thrombotic thrombocytopenic purpura: Results of a Spanish multicenter study

de la Rubia, Javier; (...); Sanz, Miguel A.

Article. 10.1016/j.transci.2010.09.018. 2010


Evaluación de un programa de conciliación e información al paciente trasplantado cardíaco.

Hernández Martín J; (...); Poveda Andrés JL

Abstract of Published Item. 10.1016/j.farma.2009.09.002. 2010

  • Open Access.

Evaluation of chimerism by quantitative PCR analysis of DNA polymorphism after allogeneic hematopoietic stem cell transplantation in a pediatric population with malignancies

Bautista, F.; (...); Verdeguer, A.

Article. 10.1111/j.1399-3046.2010.01416.x. 2011


FLT3 inhibition as a targeted therapy for acute myeloid leukemia

Sanz, Miguel; (...); Lowenberg, Bob

Article. 10.1097/CCO.0b013e32833118fd. 2009


FRAGMENT LENGTH ANALYSIS SCREENING FOR CEBPA MUTATIONS DETECTION IN ACUTE MYELOID LEUKEMIA

Fuster, O.; (...); Sanz, M. A.

Article. 2009

  • Open Access.

Imipenem/Cilastatin with or without Glycopeptide as Initial Antibiotic Therapy for Recipients of Autologous Stem Cell Transplantation: Results of a Spanish Multicenter Study

de la Rubia, Javier; (...); Sanz, Miguel A.

Article. 10.1016/j.bbmt.2008.12.505. 2009


Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q

Mallo, M.; (...); Sole, F.

Article. 10.1038/leu.2010.231. 2011


IMPACT OF CYTOGENETICS ON THE OUTCOME OF ADULT ACUTE LYMPHOBLASTIC LEUKEMIA: RESULTS FROM A SINGLE INSTITUTION

Gomez, I.; (...); Sanz, M.

Article. 2009

  • Open Access.

Incidence, Risk Factors, and Outcome of Cytomegalovirus Infection and Disease in Patients Receiving Prophylaxis with Oral Valganciclovir or Intravenous Ganciclovir after Umbilical Cord Blood Transplantation

Montesinos, Pau; (...); Sanz, Guillermo F.

Article. 10.1016/j.bbmt.2009.03.002. 2009

  • Open Access.

Independent Impact of Iron Overload and Transfusion Dependency on Survival and Leukemic Evolution in Patients with Myelodysplastic Syndrome

Sanz, Guillermo; (...); Cervera, Jose

Article. 2008


Long-term management of chronic immune thrombocytopenic purpura in adults.

Palau, Javier, Jarque, Isidro, Sanz, Miguel A

Article. 10.2147/IJGM.S4722. 2010


Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

Sanz, Miguel A.; (...); Lo-Coco, Francesco

Review. 10.1182/blood-2008-04-150250. 2009

  • Open Access.

Micafungin in invasive candidiasis among oncohematological patients

Jarque, Isidro, Angel Sanz, Miguel

Article. 10.1016/S1130-1406(09)70013-0. 2009


Modern Approaches to Treating Acute Promyelocytic Leukemia

Sanz, Miguel A., Lo-Coco, Francesco

Review. 10.1200/JCO.2010.32.1067. 2011


Open issues on bleeding and thrombosis in acute promyelocytic leukemia

Sanz, Miguel A., Montesinos, Pau

Article. 10.1016/S0049-3848(10)70013-X. 2010


Peripheral Blood CD34+Cell Count Before Apheresis in Healthy Volunteer Donors Significantly Influences the Efficacy of the Collection

Carpio, N.; (...); Sanz, M. A.

Article. 2009


Prognostic impact on survival of an unsuccessful conventional cytogenetic study in patients with myelodysplastic syndromes (MDS)

Cervera, J.; (...); Sanz, G. F.

Article. 10.1016/S0145-2126(09)70110-9. 2009


Rapid Detection of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia Using High-Resolution Melting Analysis

Fuster, Oscar; (...); Angel Sanz, Miguel

Article. 10.2353/jmoldx.2009.090043. 2009

  • Open Access.

Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is required

Pascual, Ana M.; (...); Casanova, Bonaventura

Article. 10.1177/1352458509107015. 2009


Risk-Adapted Treatment for Low- and Intermediate-Risk Acute Promyelocytic Leukemia

Sanz, Miguel A., Montesinos, Pau

Article. 10.3816/CLML.2010.s.025. 2010


Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome

Sanz, Miguel A.; (...); Lowenberg, Bob

Article. 10.1182/blood-2010-01-266007. 2010


Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group.

Sanz MA; (...); Lowenberg B

Article. 10.1182/blood-2008-05-159632. 2008


SIGNIFICANCE OF INCREASED BONE MARROW BLASTS AFTER MYELOID ENGRAFTMENT IN ADULT PATIENTS UNDERGOING UNRELATED CORD BLOOD TRANSPLANTATION

Gascon, A.; (...); Sanz, M.

Article. 2010

  • Open Access.

Single daily dose of intravenous busulfan and melphalan as a conditioning regimen for patients with multiple myeloma undergoing autologous stem cell transplantation: a phase II trial

Blanes, Margarita; (...); Sanz, Miguel A.

Article. 10.1080/10428190802630170. 2009


The differentiation syndrome in patients with acute promyelocytic leukemia: experience of the pethema group and review of the literature.

Montesinos, Pau, Sanz, Miguel A

Article. 10.4084/MJHID.2011.059. 2011

  • Open Access.

The European LeukemiaNet: achievements and perspectives

Hehlmann, Ruediger; (...); Saussele, Susanne

Article. 10.3324/haematol.2010.032979. 2011

  • Open Access.

Therapy-Related Myeloid Neoplasms in Patients With Acute Promyelocytic Leukemia Treated With All-Trans-Retinoic Acid and Anthracycline-Based Chemotherapy

Montesinos, Pau; (...); Sanz, Miguel

Article. 10.1200/JCO.2010.29.2268. 2010


Treatment of multiple myeloma in the elderly: realities and hopes

De La Rubia, Javier, Sanz, Miguel A.

Review. 10.3109/10428194.2010.530361. 2011


Unrelated Transplantation for Poor-Prognosis Adult Acute Lymphoblastic Leukemia: Long-Term Outcome Analysis and Study of the Impact of Hematopoietic Graft Source

Ferra, Christelle; (...); Ribera, Josep-Maria

Article. 10.1016/j.bbmt.2010.02.003. 2010


Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia

Valencia, A.; (...); Sanz, M. A.

Article. 10.1038/leu.2009.86. 2009


Regulación Epigenética De La Vía Wnt Por Metilación Aberrante De Sus Genes Represores En La Leucemia Mieloide Aguda

Autor/es: Ana Belén Valencia Martínez

Tesis Doctoral

Director/es: MIGUEL ÁNGEL SANZ ALONSO


Campos de estudio

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