New developments in the management of hepatitis C virus infection: focus on boceprevir.

Autores de IIS La Fe

• 

  Marina Berenguer Haym

  Autor

• Francisco Xavier López Labrador

  Autor

Grupos

• Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

Abstract

Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-a and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.

Keywords

• HCV, antiviral therapy, protease inhibitors, viral resistance