Oxaliplatin in combination with infusional 5-fluorouracil as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumors.

Autores de IIS La Fe

• Sureya Benavides Lachaise

  Autor

• Jorge Aparicio Urtasun

  Autor

• Lirios Dueñas Moscardó

  Autor

Participantes ajenos a IIS La Fe

• Pericay C
• Valladares-Ayerbes M
• Gil-Calle S
• Massutí B
• González-Flores E
• Carrato A
• Marcuello E
• Gómez A
• Cabrera E
• Queralt B
• Gómez MJ
• Guasch I
• Etxeberría A
• Alfaro J
• Campos JM
• Reina JJ
• Aranda E

Grupos

• Investigación Clínica y Traslacional en Cáncer

Abstract

We previously reported a 35% overall response rate (ORR) with biweekly 5-fluorouracil (5-FU) continuous infusion (TTD [Spanish Cooperative Group for Digestive Tumour Therapy] schedule) plus irinotecan as first-line therapy in elderly patients with metastatic colorectal cancer (mCRC). The present study also was carried out in elderly patients to determine the efficacy and safety of the same 5-FU schedule plus oxaliplatin.