Portal de recerca
- Inici
- Projectes i Estudis Clínics
- ENSAYO CLÍNICO FASE II ALEATORIZADO PARA EXPLORAR LA INFLUENCIA DEL ESTADO DE BRAF Y PI3K, EN LA EFICACIA DE FOLFIRI + BEVACIZUMAB Ó CETUXIMAB, COMO TRATAMIENTO DE PRIMERA LÍNEA DE PACIENTES CON CÁNCER COLORRECTAL METASTÁSICO CON KRAS NATIVO Y MENOS DE TRES CÉLULAS TUMORALES CIRCULANTES.
ENSAYO CLÍNICO FASE II ALEATORIZADO PARA EXPLORAR LA INFLUENCIA DEL ESTADO DE BRAF Y PI3K, EN LA EFICACIA DE FOLFIRI + BEVACIZUMAB Ó CETUXIMAB, COMO TRATAMIENTO DE PRIMERA LÍNEA DE PACIENTES CON CÁNCER COLORRECTAL METASTÁSICO CON KRAS NATIVO Y MENOS DE TRES CÉLULAS TUMORALES CIRCULANTES.
Dades bàsiques
- Protocol:
- TTD-12-02
- EURDRACT:
- 2012-000840-90
- NCT:
- Centre:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Any inici:
- 2013
- Any de finalització:
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
A critical review of HER2-positive gastric cancer evaluation and treatment: From trastuzumab, and beyond
Gomez-Martin, C; (...); Lordick, F
Review. 10.1016/j.canlet.2014.05.019. 2014
A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer.
Okuno, Keisuke; (...); Goel, Ajay
Letter. 10.1186/s12943-022-01699-2. 2023
A Phase I, Dose-Finding Study of Sorafenib in Combination with Gemcitabine and Radiation Therapy in Patients with Unresectable Pancreatic Adenocarcinoma: A Grupo Espanol Multidisciplinario en Cancer Digestivo (GEMCAD) Study
Aparicio, J; (...); Maurel, J
Article. 10.1371/journal.pone.0082209. 2014
A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study
Aparicio, J; (...); on behalf of the Spanish Germ Cell Cancer Group
Article. 10.1159/000487438. 2018
Adjuvant chemoradiation in gastric cancer: long-term outcomes and prognostic factors from a single institution
Bruixola, G; (...); Aparicio, J
Article. 10.5301/tj.5000344. 2015
Aflibercept Plus FOLFIRI for Second-line Treatment of Metastatic Colorectal Cancer: Observations from the Global Aflibercept Safety and Health-Related Quality-of-Life Program (ASQoP).
Riechelmann RP; (...); Sobrero A
Article. 10.1016/j.clcc.2019.05.003. 2019
An exosome-based liquid biopsy predicts depth of response and survival outcomes to cetuximab and panitumumab in metastatic colorectal cancer: The EXONERATE Study.
Xu, Caiming; (...); Goel, Ajay
Article. 10.1158/1078-0432.CCR-24-1934. 2025
An internally validated new clinical and inflammation-based prognostic score for patients with advanced hepatocellular carcinoma treated with sorafenib
Diaz-Beveridge, R; (...); Aparicio, J
Article. 10.1007/s12094-017-1720-4. 2018
Clinical Aspects of Usher Syndrome and the USH2A Gene in a Cohort of 433 Patients
Blanco-Kelly F; (...); Ayuso C
Article. 10.1001/jamaophthalmol.2014.4498. 2015
Clinical Impact of Circulating Tumor RAS and BRAF Mutation Dynamics in Patients With Metastatic Colorectal Cancer Treated With First-Line Chemotherapy Plus Anti-Epidermal Growth Factor Receptor Therapy
Maurel, J; (...); Montagut, C
Article. 10.1200/PO.18.00289. 2019
ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
Vargas, T; (...); de Molina, AR
Article. 10.18632/oncotarget.3130. 2015
Concordance of baseline RAS mutational status (ms) between tissue and cell-free DNA (cfDNA) and association with overall response rate (ORR) in first-line (1L) metastatic colorectal cancer (mCRC) patients (pts): PERSEIDA study (cohort 2) (NCT02792478)
Valladares-Ayerbes, M; (...); Vila, AL
Meeting Abstract. 10.1016/j.annonc.2021.08.976. 2021
Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer.
González-Billalabeitia E; (...); Spanish Germ Cell Cancer Group and the Spanish Oncology Genitourinary Group
Article. 10.1016/j.euf.2016.07.002. 2017
Controversies in the multimodality management of locally advanced rectal cancer
Díaz Beveridge R; (...); Aparicio, J
Review. 10.1007/s12032-017-0964-8. 2017
Correction to: Recommendations for follow-up of colorectal cancer survivors.
Vera R; (...); Fernández-Cebrián JM
Article. 10.1007/s12094-019-02088-w. 2019
Correction: Update on the management of elderly patients with colorectal cancer.
Soler-González G; (...); Gironés-Sarrió R
Correction. 10.1007/s12094-023-03351-x. 2024
Correlation of Hypertension and Proteinuria with Outcome in Elderly Bevacizumab-Treated Patients with Metastatic Colorectal Cancer
Feliu, J; (...); Maurel, J
Article. 10.1371/journal.pone.0116527. 2015
Correlation of RECIST, Computed Tomography Morphological Response, and Pathological Regression in Hepatic Metastasis Secondary to Colorectal Cancer: The AVAMET Study
Vera, R; (...); Viudez, A
Article. 10.3390/cancers12082259. 2020
Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial
Fernandez-Martos C; (...); Minsky BD
Article. 10.1093/annonc/mdv223. 2015
Development of a predictive model of venous thromboembolism recurrence in anticoagulated cancer patients using machine learning.
Munoz, Andres J.; (...); Hernandez-Presa, Miguel Angel
Article. 10.1016/j.thromres.2023.06.015. 2023
Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital.
Simarro J; (...); Palanca S
Article. 10.3390/cancers11081196. 2019
Dynamic nature of BRAF or KRAS p.G12C mutations in second-line therapy for advanced colorectal cancer patients: do early and late effects exist?
Contreras-Toledo, Debora; (...); Carmona-Bayonas, Alberto
Article. 10.1038/s41416-023-02563-w. 2024
Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial
Pineda, E; (...); Maurel, J
Article. 10.1177/1010428317705509. 2017
Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies
Carreño M; (...); Graus, F
Article. 10.1016/j.eplepsyres.2016.12.010. 2017
Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions
Salvador, J; (...); Garrido, P
Article. 10.1007/s12094-016-1535-8. 2017
Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions (vol 19, pg 341, 2017)
Salvador J; (...); Garrido P
Correction. 10.1007/s12094-017-1628-z. 2017
ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up
Honecker, F; (...); Horwich, A
Article. 10.1093/annonc/mdy217. 2018
European Association of Urology (EAU) Testicular Cancer Guidelines Panel: A new prognostic factor risk group classification for patients with clinical stage 1 seminoma in active surveillance.
Boormans, Joost; (...); Laguna, Pilar
Meeting Abstract. 2023
Evolution of RAS Mutations in Cell-Free DNA of Patients with Tissue RAS Wild-Type Metastatic Colorectal Cancer Receiving First-Line Treatment: The PERSEIDA Study.
Valladares-Ayerbes M; (...); Lloansí Vila A
Article. 10.3390/cancers14246075. 2022
First-line bevacizumab and capecitabine-oxaliplatin in elderly patients with mCRC: GEMCAD phase II BECOX study
Feliu, J; (...); Maurel, J
Article. 10.1038/bjc.2014.346. 2014
First-line chemotherapy with or without targeted therapies in metastatic colorectal cancer: The GEMCAD 14-01 prospective cohort
Oliveres, H.; (...); Maurel, J.
Meeting Abstract. 10.1016/j.annonc.2023.09.1796. 2023
First-line treatment with panitumumab plus FOLFIRI in elderly patients with RAS/BRAF wild-type unresectable metastatic colorectal cancer and good performance status: OPALO trial.
Feliu, Jaime; (...); Aparicio, Jorge
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.TPS3618. 2018
Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials.
Gonzalez-Gil, Celia; (...); Genesca, Eulalia
Article. 10.3324/haematol.2022.281196. 2023
Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3)
Seidel, C; (...); Bokemeyer, C
Article. 10.1016/j.ejca.2020.03.022. 2020
Hypertension as predictive factor for bevacizumab-containing first-line therapy in metastatic breast and colorectal cancer in BRECOL (GEICAM/2011-04) study.
Rodríguez-Lescure Á; (...); de la Haba-Rodriguez J
Article. 10.1007/s12094-024-03411-w. 2024
Incidence of hand-foot syndrome with capecitabine in combination with chemotherapy as first-line treatment in patients with advanced and/or metastatic gastric cancer suitable for treatment with a fluoropyrimidine-based regimen.
Gómez-Martin C; (...); López RL
Article. 10.1007/s12094-012-0858-3. 2012
Maintenance of angiogenesis inhibition with aflibercept after progression to bevacizumab in metastatic colorectal cancer: real life study in the Valencian community.
Raga, Mireia Gil; (...); Hernandez, Isabel Busquier
Article. 10.1007/s12094-022-03047-8. 2023
Management of advanced pancreatic cancer with gemcitabine plus erlotinib: efficacy and safety results in clinical practice.
Diaz Beveridge R; (...); Montalar J
Article. 10.6092/1590-8577/1570. 2014
Metastatic Colorectal Cancer. First Line Therapy for Unresectable Disease.
Aparicio J; (...); Fernandez-Montes A
Review. 10.3390/jcm9123889. 2020
Monosegment ALPPS: A new variant of the techniques for rapid hepatic regeneration. Critical review of the initial results of our series
Montalvá Orón EM; (...); López-Andújar R
Article. 10.1016/j.ciresp.2015.02.011. 2015
Multimodality Treatment of Pediatric and Adult Patients With Ewing Sarcoma: A Single-institution Experience
Diaz-Beveridge, R; (...); JORGE APARICIO URTASUN
Article. 10.1097/MPH.0000000000000339. 2015
Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma
Fischer, S; (...); Gillessen, S
Article. 10.1200/JCO.2016.69.0958. 2017
Outcome of men with relapses after adjuvant BEP for clinical stage I nonseminoma.
Fischer, Stefanie Christine; (...); Gillessen, Silke
Meeting Abstract. 10.1200/JCO.2019.37.7_suppl.510. 2019
Outcome of Men With Relapses After Adjuvant Bleomycin, Etoposide, and Cisplatin for Clinical Stage I Nonseminoma.
Fischer S; (...); Global Germ-Cell Cancer Group
Article. 10.1200/JCO.19.01876. 2020
Oxaliplatin in combination with infusional 5-fluorouracil as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumors.
Benavides M; (...); Aranda E
Article. 10.1016/j.clcc.2012.01.003. 2012
Panitumumab and irinotecan every 3 weeks is an active and convenient regimen for second-line treatment of patients with wild-type K-RAS metastatic colorectal cancer.
Carrato A; (...); Aranda E
Article. 10.1007/s12094-012-0993-x. 2013
Patterns of relapse and treatment outcome after active surveillance or adjuvant carboplatin for stage I seminoma: a retrospective study of the Spanish Germ Cell Cancer Group.
Aparicio, J.; (...); Germa, J. R.
Article. 10.1007/s12094-020-02393-9. 2021
Personalizing, not patronizing: the case for patient autonomy by unbiased presentation of management options in stage I testicular cancer
Oldenburg, J; (...); Spanish Germ Cell Canc Grp SGCCG
Review. 10.1093/annonc/mdu514. 2015
Pharmacogenetic Predictors of Outcome in Patients with Stage II and III Colon Cancer Treated with Oxaliplatin and Fluoropyrimidine-Based Adjuvant Chemotherapy
Custodio, A; (...); Feliu, J
Article. 10.1158/1535-7163.MCT-13-1109. 2014
Pharmacogenetic predictors of severe peripheral neuropathy in colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy: a GEMCAD group study
Custodio, A; (...); Feliu, J
Article. 10.1093/annonc/mdt546. 2014
PIER trial: Neoadjuvant therapy with panitumumab (P) and mFOLFOX-6 in an enriched population of patients with T3 rectal adenocarcinoma of the middle third with clear mesorectal fascia.
Fernandez-Martos, Carlos; (...); Vera, Ruth
Meeting Abstract. 10.1200/JCO.2018.36.4_suppl.TPS875. 2018
Pleuropulmonary angiosarcoma involving the liver, the jejunum and the spine, developed from chronic tuberculosis pyothorax: Multidisciplinary approach and review of literature
Bruixola G; (...); Aparicio J
Review. 10.1016/j.lungcan.2014.07.012. 2014
Precision medicine in metastatic colorectal cancer: targeting KRAS G12C mutation
Article. 10.21037/tgh-24-28. 2024
Predicting major bleeding events in anticoagulated cancer patients with venous thromboembolism using real-world data and machine learning.
Martin, Andres J. Munoz; (...); Hernandez-Presa, Miguel Angel
Meeting Abstract. 2022
Predicting recurrence of venous thromboembolism in anticoagulated cancer patients using real-world data and machine learning.
Martin, Andres J. Munoz; (...); Hernandez-Presa, Miguel Angel
Meeting Abstract. 2022
Prediction model for major bleeding in anticoagulated patients with cancer-associated venous thromboembolism using machine learning and natural language processing.
Munoz Martin, Andres J; (...); Hernandez-Presa, Miguel Angel
Article. 10.1007/s12094-024-03586-2. 2024
Predictors of positive challenge with kiwi in children
Sabido, P; (...); Mazon, A
Meeting Abstract. 2018
Preoperative Chemotherapy in Patients With Intermediate-Risk Rectal Adenocarcinoma Selected by High-Resolution Magnetic Resonance Imaging: The GEMCAD 0801 Phase II Multicenter Trial
Fernandez-Martos, C; (...); Pericay, C
Editorial Material. 10.1634/theoncologist.2014-0233. 2014
Primary Mesenteric Undifferentiated Pleomorphic Sarcoma Masquerading as a Colon Carcinoma: A Case Report and Review of the Literature.
Diaz-Beveridge R; (...); Aparicio J
Article. 10.1155/2015/532656. 2015
Prognosis of anaemia in disseminated testicular germ cell tumours. On behalf of the Spanish Germ Cell Cancer Group (SGCCG)
Torralba, EG; (...); Billalabeitia, EG
Meeting Abstract. 2019
Prognostic Factor Risk Groups for Clinical Stage I Seminoma: An Individual Patient Data Analysis by the European Association of Urology Testicular Cancer Guidelines Panel and Guidelines Office.
Boormans, Joost L; (...); Laguna, M Pilar
Article. 10.1016/j.euo.2023.10.014. 2023
Prognostic factors for relapse in stage I seminoma: a new nomogram derived from three consecutive, risk-adapted studies from the Spanish Germ Cell Cancer Group (SGCCG)
Aparicio J; (...); Germà JR
Article. 10.1093/annonc/mdu437. 2014
Prognostic factors in metastatic seminomatous germ cell tumours and elevated human chorionic gonadotrophin (HCG): A study of the G3
Seidel, C; (...); Bokemeyer, C
Meeting Abstract. 2019
Prognostic impact of LDH and HCG levels in marker-positive seminomas
Seidel, Christoph Alexander; (...); Bokemeyer, Carsten
Meeting Abstract. 2020
Prognostic significance of thromboembolic events in chemotherapy-treated germ cell tumors.
Gonzalez-Billalabeitia, Enrique; (...); Germa-Lluch, Jose R.
Meeting Abstract. 10.1200/jco.2015.33.15_suppl.4536. 2015
Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients
Gonzalez-Billalabeitia, E; (...); Spanish Germ Cell Cancer Group
Article. 10.1093/jnci/djw265. 2017
Ramucirumab effectiveness in patients with advanced gastric cancer or gastro-esophageal junction adenocarcinoma in clinical practice in Spain: Sub-analysis of RAMIS study
Longo, F; (...); Sedano, MO
Meeting Abstract. 10.1016/j.annonc.2020.04.125. 2020
Randomized phase II clinical trial to evaluate the efficacy of second line FOLFIRI-panitumumab in patients with RAS wild -type metastatic colorectal cancer who have received FOLFOXpanitumumab in first -line (BEYOND)
Aparicio, J; (...); Maurel, J
Meeting Abstract. 10.1093/annonc/mdz155.190. 2019
Randomized phase II trial of FOLFIRI-panitumumab compared with FOLFIRI alone in patients with RAS wild-type circulating tumor DNA metastatic colorectal cancer beyond progression to first-line FOLFOX-panitumumab: the BEYOND study (GEMCAD 17-01)
Aparicio, Jorge; (...); Maurel, Joan
Article. 10.1007/s12094-022-02868-x. 2022
Randomized phase II trial of second-line FOLFIRI-panitumumab vs FOLFIRI alone in Ras wild type (wt) metastatic colorectal cancer (mCRC) patients beyond progression to first-line FOLFOX-panitumumab: BEYOND study (GEMCAD 17-01)
Aparicio, J; (...); Maurel, J
Meeting Abstract. 10.1016/j.annonc.2021.08.937. 2021
Real-life use of ramucirumab in gastric cancer in Spain: the RAMIS study.
Longo F; (...); Díaz-Cerezo S
Article. 10.2217/fon-2020-1216. 2021
Real-world dosing patterns of regorafenib for patients with metastatic colorectal cancer in Spain: the RE-SEARCH study.
López Muñoz AM; (...); Martín Gómez T
Article. 10.1007/s12094-024-03630-1. 2024
Recent treatment advances in clinical stage i nonseminomatous germ cell tumors.
Letter. 10.1016/j.acuro.2020.08.014. 2021
Recommendations for follow-up of colorectal cancer survivors
Vera, R; (...); Fernandez-Cebrian, JM
Article. 10.1007/s12094-019-02059-1. 2019
Recommendations for SIR-Spheres Y-90 resin microspheres in chemotherapy-refractory/intolerant colorectal liver metastases
Aranda, E; (...); Feliu, J
Article. 10.2217/fon-2017-0220. 2017
Retrospective real-world data study using natural language processing to describe treatment sequence and clinicopathological patterns in patients with metastatic colorectal cancer in five Spanish institutions
Vera Garcia, R.; (...); Mondejar Solis, R.
Meeting Abstract. 10.1016/j.annonc.2023.04.343. 2023
Safety and efficacy of sorafenib in the treatment of advanced hepatocellular carcinoma: a single center experience
Imedio ER; (...); Salcedo JM
Article. 10.1007/s12032-014-0948-x. 2014
SEOM Clinical Guideline of localized rectal cancer (2016)
Gonzalez-Flores, E; (...); Fernandez-Martos, C
Article. 10.1007/s12094-016-1591-0. 2016
SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer (2018)
Gomez-Espana, MA; (...); Vera, R
Article. 10.1007/s12094-018-02002-w. 2019
SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer 2015
Aranda, E; (...); Garcia-Carbonero, R
Article. 10.1007/s12094-015-1434-4. 2015
SEOM clinical guidelines for the management of germ cell testicular cancer (2016)
Aparicio, J; (...); Garcia-del-Muro, X
Article. 10.1007/s12094-016-1566-1. 2016
SEOM clinical guidelines in gestational trophoblastic disease (2017)
Santaballa, A; (...); Garcia-Martinez, E
Article. 10.1007/s12094-017-1793-0. 2018
SEOM clinical guidelines to primary prevention of cancer (2018).
Bayo J; (...); Santaballa A
Article. 10.1007/s12094-018-02016-4. 2019
SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022).
Fernandez Montes, Ana; (...); Aparicio, Jorge
Article. 10.1007/s12094-023-03199-1. 2023
SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023).
Arranz Arija, Jose Angel; (...); Gonzalez-Billalabeitia, Enrique
Article. 10.1007/s12094-024-03532-2. 2024
Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study.
Valladares-Ayerbes M; (...); Lloansí Vila A
Article. 10.1007/s12094-024-03487-4. 2024
Synchronous versus metachronous brain metastasis from testicular germ cell tumors (TGCT): an analysis from the Spanish Germ Cell Cancer Group data base
Girones, R; (...); SGCCG
Article. 10.1007/s12094-014-1179-5. 2014
The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3).
Seidel C; (...); Oing C
Article. 10.1007/s00345-021-03635-3. 2021
Treatment and Outcome of Patients with Stage IS Testicular Cancer: A Retrospective Study from the Spanish Germ Cell Cancer Group.
Aparicio J; (...); Terrasa J
Article. 10.1097/JU.0000000000000366. 2019
Update on the management of elderly patients with colorectal cancer.
Soler-Gonzalez, Gemma; (...); Girones-Sarrio, Regina
Article. 10.1007/s12094-023-03243-0. 2023
Validation of the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram after surgery for localized pancreatic adenocarcinoma: Long-term results from a Spanish pancreatic cancer surgery reference centre
Salvador, C.; (...); Aparicio, J.
Meeting Abstract. 10.1016/S0959-8049(16)31204-7. 2015
Venous thromboembolism recurrence during anticoagulant treatment in gastrointestinal cancer patients
Munoz Martin, A.; (...); Angel Hernandez-Presa, M.
Meeting Abstract. 2022