Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value?

Autores de IIS La Fe

• Esperanza Such Taboada

  Autor

• José Vicente Cervera Zamora

  Autor

• Marta Isabel Roca Marugán

  Autor

• 

  María Ángeles Tormo Mas

  Autor

• Fernando Carbonell Tatay

  Autor

• Josep Lluís Melero Ferrer

  Autor

• Jordi Grau Hernandez

  Autor

Participantes ajenos a IIS La Fe

• Ademà V
• Hernández JM
• Abáigar M
• Lumbreras E
• Calull A
• Dominguez E
• Arenillas L
• Mallo M
• García F
• González T
• Luño E
• Sanzo C
• Martín ML
• Fernández M
• Costa D
• Blázquez B
• Barreña B
• Marco F
• Batlle A
• Buño I
• Martínez-Laperche C
• Noriega V
• Collado R
• Ivars D
• Vallcorba I
• Delgado E
• Vargas MT
• Salido M
• Espinet B
• Melero C
• Florensa L
• Pedro C
• Solé F

Grupos

• Hematología y Hemoterapia

Abstract

Chromosomal abnormalities are detected in 40-60% of patients with de novo myelodysplastic syndromes (MDS). This study used the FISH technique in 773 patients with de novo MDS without evidence of monosomy 7 (-7) or 7q deletion (7q-) by conventional G-banding cytogenetics (CC) to analyze their prognostic impact by FISH alone. FISH detected -7/7q- in 5.2% of patients. Presence of -7/7q- was associated with shorter overall survival than absence of such aberrations. Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC.