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Multivariable time-dependent analysis of the impact of azacitidine in patients with lower-risk myelodysplastic syndrome and unfavorable specific lower-risk score

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Falantes J
  • Delgado RG
  • Calderón-Cabrera C
  • Márquez-Malaver FJ
  • Valcarcel D
  • de Miguel D
  • Bailén A
  • Bargay J
  • Bernal T
  • González-Porras JR
  • Tormo M
  • Xicoy B
  • Nomdedeu B
  • Brunet S
  • Sánchez J
  • Jurado AF
  • Pérez-Simón JA
  • Spanish Group of Myelodysplastic Syndromes (GESMD)

Grupos

Abstract

Scoring systems for lower-risk myelodysplastic syndrome (LR-MDS) recognize patients with a poorer than expected outcome. This study retrospectively analyzes the role of azacitidine in LR-MDS with adverse risk score and compared to an historical cohort treated with best supportive care or erythropoiesis-stimulating agents. Overall response to AZA was 40%. One and 2-year probabilities of survival were 62% and 45% for AZA vs. 25% and 11% (P = 10(-4)). In a multivariable time-dependent analysis, response to AZA (CR/PR/HI) was associated with an improved survival (HR = 0.234, 95% CI, 0.063-0.0863; P = 0.029). Thrombocytopenia (<50 x 10(9) L-1) is confirmed as an adverse parameter in LR-MDS (HR = 1.649, 95% CI, 1.012-2.687; P = 0.045). (C) 2014 Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0145-2126, 1873-5835

LEUKEMIA RESEARCH  PERGAMON-ELSEVIER SCIENCE LTD

Tipo:
Article
Páginas:
52-57
PubMed:
25487012
Factor de Impacto:
1,049 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 17

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Keywords

  • Lower-risk myelodysplastic syndrome; Outcome; Azacitidine

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