Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

Fecha de publicación: 01/08/2015

Autores de IIS La Fe

Ana Rosa Cid Haro

Autor

Participantes ajenos a IIS La Fe

Civaschi E
Klersy C
Melazzini F
Pujol-Moix N
Santoro C
Cattaneo M
Lavenu-Bombled C
Bury L
Minuz P
Nurden P
Cuker A
Latger-Cannard V
Favier R
Nichele I
Noris P
European Haematology Association - Scientific Working Group on Thrombocytopenias

Grupos

Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.

Datos de la publicación

ISSN/ISSNe:: 0007-1048, 1365-2141
Tipo:: Article
Páginas:: 559-563
DOI:: 10.1111/bjh.13458
PubMed:: 25899604
Factor de Impacto:: 2,297 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Filiaciones

Civaschi E:: Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Pavia, Italy
Klersy C:: Service of Biometry & Statistics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
Melazzini F:: Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Pavia, Italy
Pujol-Moix N:: Universitat Autònoma de Barcelona & Institut de Recerca Biomèdica Sant Pau, Barcelona, Spain
Santoro C:: Ematologia, Policlinico Umberto 1, Università Sapienza, Rome, Italy
Cattaneo M:: Dipartimento di Scienze della Salute, Medicina III, Ospedale San Paolo, Università degli Studi di Milano, Milano, Italy
Lavenu-Bombled C:: AP-HP, Hôpital Bicêtre, Hématologie Biologique/Centre de Référence Pathologies Plaquettaires, Le Kremlin Bicêtre, France
Bury L:: Department of Medicine, University of Perugia, Perugia, Italy
Minuz P:: Department of Medicine, University of Verona, Verona, Italy
Nurden P:: Plateforme Technologique et d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France
Cid AR:: Unidad de Hemostasia y Trombosis, La Fe University Hospital, Valencia, Spain
Cuker A:: Department of Medicine and Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Latger-Cannard V:: Centre de Compétence Nord-Est des Pathologies Plaquettaires from the Frame of the Reference French Centre and Service d'Hématologie Biologique, Centre Hospitalo-Universitaire, Nancy, France
Favier R:: Haematological Laboratory, AP-HP, Armand Trousseau Children Hospital, French Reference Centre for Inherited Platelet Disorders, Paris, France

Inserm U1170, Villejuif, France
Nichele I:: Department of Cell Therapy and Haematology, San Bortolo Hospital, Vicenza, Italy
Noris P:: Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Keywords

inherited platelet disorders; bleeding diathesis; pregnancy; perinatal haemostasis; bleeding risk

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