COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review.

Fecha de publicación: 04/08/2023 Fecha Ahead of Print: 04/08/2023

Autores de IIS La Fe

• Elena Satorres Pérez

  Autor

• Alicia Martínez Varea

  Autor

• 

  José Morales Roselló

  Autor

Grupos

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Objective: To review the current knowledge concerning COVID-19 vaccination and assisted reproductive techniques (ART). Methods: A systematic review in Pubmed-Medline, the Cochrane Database, the Web of Science, and the National Guideline was performed. Studies were selected if they were primary studies, included vaccinated (case) and unvaccinated (control) patients, and described fertility treatment response. Results: A total of 24 studies were selected. Outcomes related to the association between COVID-19 vaccination and ART were collected. The vast majority of studies found no statistical differences concerning oocyte stimulation response, embryo quality, implantation rates, or pregnancy outcome (clinical or biochemical pregnancy rates and losses) when comparing cases and controls. Similarly, no differences were found when comparing different types of vaccines or distinct ART (artificial insemination, in vitro fertilization, and embryo transfer of frozen embryos). Conclusions: Patients receiving ART and health care professionals should be encouraged to complete and recommend COVID-19 vaccination, as the available evidence regarding assisted reproductive outcomes is reassuring.

Keywords

• COVID-19; SARS-CoV-2; assisted reproductive techniques (ART); embryo; fertility; in vitro fertilization (IVF); pregnancy; reproduction; vaccine