Portal de recerca
Optimización del manejo antenatal de mujeres con amenaza de parto pretérmino mediante modelos de predicción: estudio clínico randomizado multicéntrico (OPTIM-PTL).
Dades bàsiques
- Protocol:
- HCB/2020/0938
- EURDRACT:
- 2020-005202-26
- NCT:
- Centre:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Any inici:
- 2021
- Any de finalització:
- 2023
Objectius del projecte
Objetivo Principal: Evaluar si la implementación de un modelo de predicción de riesgo de parto pretérmino espontáneo o de infección intra-amniótica: 1. optimiza el manejo antenatal (respecto corticoides, tocolisis, antibióticos, estancia hospitalaria) sin empeorar los resultados perinatales. Objetivos Secundarios: Evaluar si la implementación de un modelo de predicción de riesgo (de parto pretérmino espontáneo o de infección intra-amniótica): 2. es una estrategia costo-efectiva. 3. mejora el pronóstico neonatal (en prematuros < 30 semanas), y reduce la morbilidad materna de tipo infeccioso. 4. mejora el neurodesarrollo al 1, 2 y 5 años de vida.
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
Are Infants Born After an Episode of Suspected Preterm Labor at Risk of ADHD? A 30-Month Follow-up Study.
Navalon, Pablo; (...); Garcia-Blanco, Ana
Article. 10.1016/j.ajog.2022.05.065. 2022
Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study)
Cobo, T; (...); Gratacos, E
Article. 10.1136/bmjopen-2021-054711. 2021
Assessment of Dispersion and Bubble Entropy Measures for Enhancing Preterm Birth Prediction Based on Electrohysterographic Signals
Nieto-del-Amor, F; (...); Prats-Boluda, G
Article. 10.3390/s21186071. 2021
Automatic semantic segmentation of EHG recordings by deep learning: An approach to a screening tool for use in clinical practice.
Nieto-del-Amor, Felix; (...); Prats-Boluda, Gema
Article. 10.1016/j.cmpb.2024.108317. 2024
Combination of Feature Selection and Resampling Methods to Predict Preterm Birth Based on Electrohysterographic Signals from Imbalance Data.
Nieto-del-Amor, Felix; (...); Ye-Lin, Yiyao
Article. 10.3390/s22145098. 2022
COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review.
Satorres-Pérez E, Martínez-Varea A, Morales-Roselló J
Article. 10.3390/jpm13081232. 2023
Cumulative life stressors and stress response to threatened preterm labour as birth date predictors
Campos-Berga, Laura; (...); Garcia-Blanco, Ana
Article. 10.1007/s00404-021-06251-z. 2021
Diagnosis of intraamniotic inflammation by measuring vaginal interleukin-6 in patients with cervical insufficiency: could amniocentesis be avoided?
Diago Muñoz DM; (...); Diago Almela, Vicente Jose
Article. 10.1080/14767058.2022.2029838. 2022
Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia.
Garrido-Gomez T; (...); Simon C
Article. 10.7554/eLife.70753. 2021
Early Fetal Growth Restriction of Both Twins in a Transgender Man.
Martinez-Varea, Alicia; (...); Diago-Almela, Vicente
Article. 10.1155/2022/2905539. 2022
Impact of Maternal Smoking on Obstetric and Neonatal Outcomes in Twin Pregnancies: A Narrative Review
Julia-Burches, Cristina; (...); Diago-Almela, Vicente
Review. 10.3390/jcm13237329. 2024
Optimized Feature Subset Selection Using Genetic Algorithm for Preterm Labor Prediction Based on Electrohysterography.
Nieto-Del-Amor F; (...); Ye-Lin Y
Article. 10.3390/s21103350. 2021
Outperformance of interleukin-6 over placental alpha microglobulin-1 to predict preterm delivery in symptomatic women.
Roca-Prats, Alba; (...); Perales-Marin, Alfredo
Article. 10.1016/j.ajogmf.2023.101125. 2023
Perinatal Outcomes of Monochorionic Twin Pregnancies Conceived Naturally Versus through Assisted Reproductive Techniques.
Martinez-Varea, Alicia; (...); Diago-Almela, Vicente
Article. 10.3390/jcm12186097. 2023
Rescue doses of antenatal corticosteroids, childrens neurodevelopment, and salivary cortisol after a threatened preterm labor: A 30-month follow-up study.
Navalon, Pablo; (...); Garcia-Blanco, Ana
Article. 10.1016/j.ajogmf.2023.100918. 2023
Severe COVID-19 Infection during Pregnancy Requiring ECMO: Case Report and Review of the Literature.
Diago-Munoz, Diana; (...); Diago-Almela, Vicente
Case Reports. 10.3390/jpm13020263. 2023
sFlt-1/PlGF ratio as a predictor of pregnancy outcomes in twin pregnancies: a systematic review.
Satorres, Elena, Martinez-Varea, Alicia, Diago-Almela, Vicente
Article. 10.1080/14767058.2023.2230514. 2023
Temperamental and psychomotor predictors of ADHD symptoms in children born after a threatened preterm labour: a 6-year follow-up study
Navalón P; (...); García-Blanco A
Article. 10.1007/s00787-022-02073-9. 2022
The effectiveness of cervical cerclage in twin pregnancies with a mid-trimester short cervix: A retrospective cohort study.
Ferro, Jaime; (...); Serra, Vicente
Article. 10.1016/j.ejogrb.2023.12.029. 2023
The sFlt-1/PlGF Ratio at 12, 24, and 32 Weeks Gestation in Twin Pregnancies as a Predictor of Late Preterm Birth and Perinatal Event Secondary to Prematurity.
Satorres-Pérez E; (...); Diago-Almela V
Article. 10.3390/jcm13092699. 2024
The sFlt-1/PlGF Ratio at 12, 24, and 32 Weeks Gestation in Twin Pregnancies as a Predictor of Placental Dysfunction
Satorres-Perez, Elena; (...); Diago-Almela, Vicente
Article. 10.3390/jcm13061784. 2024
Understanding the course of Attention-Deficit/Hyperactivity Disorder in Children Born After a Suspected Preterm Labor: A 6-Year Cohort Study.
Buesa, Julia; (...); Garcia-Blanco, Ana
Article. 10.1016/j.ajogmf.2024.101289. 2024
Uterine myoelectrical activity as biomarker of successful induction with Dinoprostone: Influence of parity
Diaz-Martinez, Alba; (...); Prats-Boluda, Gema
Article. 10.1016/j.bbe.2022.12.0040168-8227. 2023