Portal de investigación
Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Castillo MI
- Ribate VE
- Muñoz CM
- Abinzano CMJ
- Barranco IA
- Nieto CR
- Pampliega VM
- Blanco ML
- de Andrés ÁS
- de Oteyza PJ
- Del Castillo BT
- Font GI
- Cayuela JA
- Díez-Campelo M
- Sánchez AR
- Vercet SC
- Díaz TM
- Grupo Español de Síndromes Mielodisplásicos (GESMD)
Grupos
Abstract
BACKGROUND: In myelodysplastic neoplasms (MDS), the 20q deletion [del(20q)] is a recurrent chromosomal abnormality that it has a high co-occurrence with U2AF1 mutations. Nevertheless, the prognostic impact of U2AF1 in these MDS patients is uncertain and the possible clinical and/or prognostic differences between the mutation type and the mutational burden are also unknown. METHODS: Our study analyzes different molecular variables in 100 MDS patients with isolated del(20q). RESULTS & CONCLUSIONS: We describe the high incidence and negative prognostic impact of U2AF1 mutations and other alterations such as in ASXL1 gene to identify prognostic markers that would benefit patients to receive earlier treatment.
© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Datos de la publicación
- ISSN/ISSNe:
- 2045-7634, 2045-7634
- Tipo:
- Article
- Páginas:
- 16788-16792
- DOI:
- 10.1002/cam4.6300
- PubMed:
- 37403747
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 1,144 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Cancer Medicine WILEY
Citas Recibidas en Web of Science: 2
Citas Recibidas en Scopus: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- 20q deletion; U2AF1 mutations; myelodysplastic neoplasms; prognosis; quantitative allele-specific PCR
Campos de Estudio
Cita
Castillo MI,Ribate VE,Muñoz CM,SANTILLANA SG,TABOADA SE,CASTERÁ ME,Abinzano CMJ,Barranco IA,Nieto CR,Pampliega VM,Blanco ML,de Andrés ÁS,de Oteyza PJ,Del Castillo BT,Font GI,Cayuela JA,Díez M,Sánchez AR,Vercet SC,Díaz TM,Grupo Español de Síndromes Mielodisplásicos (. Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion. Cancer Med. 2023. 12. (16):p. 16788-16792. IF:2,900. (2).