Portal de investigación
WT1 isoform expression pattern in acute myeloid leukemia.
Autores de IIS La Fe
Grupos
Abstract
WT1 plays a dual role in leukemia development, probably due to an imbalance in the expression of the 4 main WT1 isoforms. We quantify their expression and evaluate them in a series of AML patients. Our data showed a predominant expression of isoform D in AML, although in a lower quantity than in normal CD34+ cells. We found a positive correlation between the total WT1 expression and A, B and C isoforms. The overexpression of WT1 in AML might be due to a relative increase in A, B and C isoforms, together with a relative decrease in isoform D expression.
Datos de la publicación
- ISSN/ISSNe:
- 0145-2126, 1873-5835
- Tipo:
- Article
- Páginas:
- 1744-1749
- PubMed:
- 24211094
- Factor de Impacto:
- 1,072 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
LEUKEMIA RESEARCH PERGAMON-ELSEVIER SCIENCE LTD
Citas Recibidas en Web of Science: 14
Documentos
- No hay documentos
Filiaciones
Keywords
- Acute myeloid leukemia, WT1 isoforms
Campos de Estudio
Cita
LUNA I,SUCH E,CERVERA J,BARRAGÁN E,IBAÑEZ M,GÓMEZ I,LÓPEZ M,LLOP M,FUSTER O,DOLZ S,OLTRA S,ALONSO C,VERA B,LORENZO I,MARTÍNEZ D,MONTESINOS P,SENENT ML,MOSCARDÓ F,BOLUFER P,SANZ MA. WT1 isoform expression pattern in acute myeloid leukemia. Leuk. Res. 2013. 37. (12):p. 1744-1749. IF:2,692. (2).