Influence of Intravitreal Therapy on Choroidal Thickness in Patients with Diabetic Macular Edema.

Fecha de publicación: 01/01/2023 Fecha Ahead of Print: 01/01/2023

Autores de IIS La Fe

Patricia Udaondo Mirete

Autor
Enrique España Gregori

Autor

Participantes ajenos a IIS La Fe

Munoz-Morata, Carmen
Albarran-Diego, Cesar

Grupos

Biomedicina Molecular, Celular y Genómica

Leader

José María Millán Salvador
Investigación en Neuroinmunología y Esclerosis Múltiple

Leader

Bonaventura Casanova Estruch

Abstract

OBJECTIVE: This study aimed to analyze the variation in subfoveal choroidal thickness (SFCT) and its relationship with the variation in central macular thickness (CME) in response to intravitreal therapy with an antiangiogenic (anti-VEGF) drug or corticosteroid in type 2 diabetic patients with diabetic macular edema (DME). MATERIAL AND METHODS: This retrospective study included 70 eyes of 35 patients: 26 eyes received 4-5 intravitreal injections of aflibercept, 26 eyes were treated with a single intravitreal implant injection of dexamethasone, and 18 eyes without DME did not receive intravitreal therapy. SPECTRALIS® optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany) was used to measure the SFCT and CME before and at the end of the follow-up period. RESULTS: The mean reductions in CME were 18.8 +/- 14.7% (aflibercept) and 29.7 +/- 16.9% (dexamethasone). The mean reductions in SFCT were 13.8 +/- 13.1% (aflibercept) and 19.5 +/- 9.6% (dexamethasone). The lowering effects of both parameters were significantly greater in the group treated with the dexamethasone implant (p = 0.022 and p = 0.046 for CMT and SFCT, respectively). Both therapies significantly decreased both CME and SFCT, independent of factors such as age, sex, previous intravitreal therapy, antidiabetic treatment, and the time of diabetes progression. There were no changes in the mean values of CME and SFCT in the untreated eyes. CONCLUSIONS: SFCT significantly decreased in response to intravitreal therapy with anti-VEGF or corticosteroids, irrespective of age, sex, previous intravitreal therapy, antidiabetic treatment, and the time of diabetes progression. There was a correlation between the changes in CME and SFCT after intravitreal therapy with aflibercept or dexamethasone implantation. SFCT was not a good predictor of the CME response but could be used to monitor the response to treatment. Local intravitreal therapy only affected the treated eye.

Datos de la publicación

ISSN/ISSNe:: 2077-0383, 2077-0383
Tipo:: Article
Páginas:: -
DOI:: 10.3390/jcm12010348
PubMed:: 36615148
Factor de Impacto:: 1,040 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Udaondo Mirete P:: Department of Ophthalmology, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain

Aiken Clinic, 46004 Valencia, Spain

Department of Surgery, Universidad de Valencia, 46010 Valencia, Spain
Munoz-Morata, Carmen:: Department of Surgery, Universidad de Valencia, 46010 Valencia, Spain
Albarran-Diego, Cesar:: Department of Surgery, Universidad de Valencia, 46010 Valencia, Spain
Espana-Gregori, Enrique:: Department of Ophthalmology, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain

Department of Surgery, Universidad de Valencia, 46010 Valencia, Spain

Keywords

OCT; aflibercept; anti-VEGF; choroid; dexamethasone implant; diabetic macular edema; intravitreal therapy; ranibizumab

Campos de Estudio

Proyectos y Estudios Clínicos

PATRONES DE RM CEREBRAL Y MEDULAR EN RELACION CON LA PRESENCIA DE AUTOANTIGENOS NEURONALES RECONOCIDOS POR INMUNOGLOBULINAS M PRESENTES EN EL LIQUIDO CEFALORRAQUIDEO DE PACIENTES DE ESCLEROSIS MULTIPLE.

Investigador Principal: ISABEL BOSCÁ BLASCO

MERCK SERONO DR. CASANOVA . ALMIRALL S.A; FUNDACIÓN BIOGEN IDEC; MERCK S.L.U; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010