Norovirus infection as a model of chronic or recurrent infection in common variable immunodeficiency.

Autores de IIS La Fe

• Pedro Moral Moral

  Autor

• Marta Dafne Cabañero Navalón

  Autor

• Víctor García Bustos

  Autor

• María Nuñez Beltrán

  Autor

• Miguel Salavert Lletí

  Autor

Grupos

• Infección Grave

• Investigacion clínica en enfermedades crónicas e Infección por el VIH

Abstract

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency (PID) in general population. PID are genetic diseases that share a dysfunction in the immune system entailing a greater risk of both chronic and recurrent infections. These patients can also develop chronic gastrointestinal infections caused by norovirus with persistent viral dissemination, which can be detected months after primoinfection. Additionally, a proportion of CVID patients show a typical severe enteropathy presenting with recurrent diarrhoea, intestinal malabsorption, inflammatory lesions, and villous atrophy. Some studies have related this enteropathy with chronic intestinal infection caused by norovirus.

©The Author 2022. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).

Keywords

• common variable immunodeficiency; Norovirus; enteropathy