Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency.

Autores de IIS La Fe

• Alba María Polonio Ramírez

  Autor

• Juan Antonio García Velasco

  Autor

• Sonia Herraiz Raya

  Autor

Grupos

• Endocrinología Reproductiva e Infertilidad

  Leader

  José Remohí Giménez

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Premature ovarian insufficiency is a common disorder affecting young women and represents the worst-case ovarian scenario due to the substantial impact on the reproductive lifespan of these patients. Due to the complexity of this condition, which is not fully understood, non-effective treatments have yet been established for these patients. Different experimental approaches are being explored and strategies based on stem cells deserve special attention. The regenerative and immunomodulatory properties of stem cells have been successfully tested in different tissues, including ovary. Numerous works point out to the efficacy of stem cells in POI treatment, and a wide range of clinical trials have been developed in order to prove safety and effectiveness of stem cells therapy-in diminished ovarian reserve and POI women. The main purpose of this review is to describe the state of the art of the treatment of POI involving stem cells, especially those that use mobilization of stem cells or paracrine signaling.

Keywords

• autologous stem cell ovarian transplant, follicular rescue, mobilization, ovarian rejuvenation, premature ovarian insufficiency, stem cells