Portal de investigación
Reasons for noncompliance with the national guidelines for initial antiretroviral therapy of HIV-infected patients in Spain, 2010-2015
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Gonzalez, J
- Jarrin, I
- del Amo, J
- Navarro, ML
- Gonzalez, MI
- Blanco, JL
- Sobrino, P
- Hernando, V
- Alejos, B
- Alvarez, D
- Jarrin, I
- Sanz, N
- Moreno, C
- Munoz-Fernandez, MA
- Garcia-Merino, I
- Rico, CG
- de la Fuente, JG
- Torre, AG
- Merino, E
- Boix, V
- Giner, L
- Gadea, C
- Portilla, I
- Pampliega, M
- Diez, M
- Rodriguez, JC
- Sanchez-Paya, J
- Gomez, JL
- Hernandez, J
- Aleman, MR
- Alonso, MD
- Hernandez, MI
- Diaz-Flores, F
- Pelazas, R
- Lirola, AL
- Asensi, V
- Valle, E
- Carton, JA
- Carmenado, MER
- Rubio, R
- Pulido, F
- Bisbal, O
- Hernando, A
- Lagarde, M
- Matarranz, M
- Dominguez, L
- Bermejo, L
- Santacreu, M
- Iribarren, JA
- Arrizabalaga, J
- Aramburu, MJ
- Camino, X
- Rodriguez-Arrondo, F
- von Wichmann, MA
- Tome, LP
- Goenaga, MA
- Bustinduy, MJ
- Galparsoro, HA
- Ibarguren, M
- Umerez, M
- Gutierrez, F
- Padilla, S
- Navarro, A
- Montolio, F
- Robledano, C
- Colome, JG
- Adsuar, A
- Pascual, R
- Fernandez, M
- Garcia, E
- Garcia, JA
- Barber, X
- Muga, R
- Tor, J
- Sanvisens, A
- de Quiros, JCLB
- Miralles, P
- Gutierrez, I
- Padilla, B
- Gijon, P
- Carrero, A
- Aldamiz-Echevarria, T
- Tejerina, F
- Parras, FJ
- Balsalobre, P
- Diez, C
- Vidal, F
- Peraire, J
- Vilades, C
- Veloso, S
- Vargas, M
- Lopez-Dupla, M
- Olona, M
- Rull, A
- Rodriguez-Gallego, E
- Alba, V
- Gonzalez-Garcia, J
- Arnalich, F
- Arribas, JR
- Bernardino, JI
- Castro, JM
- Escosa, L
- Herranz, P
- Hontanon, V
- Garcia-Bujalance, S
- Lopez-Hortelano, MG
- Gonzalez-Baeza, A
- Martin-Carbonero, ML
- Mayoral, M
- Mellado, MJ
- Mican, R
- Montejano, R
- Montes, ML
- Moreno, V
- Perez-Valero, I
- Rodes, B
- Sainz, T
- Sendagorta, E
- Stella, NC
- Valencia, E
- Blanco, JR
- Oteo, JA
- Lbarra, V
- Metola, L
- Perez-Martinez, L
- Ramos, C
- Arazo, P
- Gil, D
- Dalmau, D
- Jaen, A
- Sanmarti, M
- Cairo, M
- Martinez-Lacasa, J
- Velli, P
- Font, R
- Xercavins, M
- Rivero, M
- Reparaz, J
- de Alda, MGR
- Irigoyen, C
- Arraiza, MJ
- Segura, F
- Amengual, MJ
- Navarro, G
- Sala, M
- Cervantes, M
- Pineda, V
- Anton, E
- Nogueras, MM
- de los Santos, I
- Sanz, JS
- Aparicio, AS
- Cepeda, CS
- Fraile, LGF
- Moreno, S
- Casado, JL
- Dronda, F
- Elias, MJP
- Ayerbe, CG
- Gutierrez, C
- Madrid, N
- Terron, SD
- Ansa, U
- Serrano, S
- Vivancos, MJ
- Garcia, F
- Hernandez, J
- Pena, A
- Munoz, L
- Perez, AB
- Alvarez, M
- Chueca, N
- Vinuesa, D
- Del Romero, J
- Rodriguez, C
- Puerta, T
- Carrio, JC
- Ballesteros, J
- Antela, A
- Losada, E
- Riera, M
- Penaranda, M
- Leyes, M
- Ribas, MA
- Campins, AA
- Fanjul, F
- Murillas, J
- Homar, F
- Santos, J
- Marquez, M
- Viciana, I
- Palacios, R
- Gonzalez, CM
- Viciana, P
- Espinosa, N
- Lopez-Cortes, LF
- Podzamczer, D
- Ferrer, E
- Imaz, A
- Tiraboschi, J
- Silva, A
- Saumoy, M
- Ribera, E
- Olalla, J
- del Arco, A
- de la Torre, J
- Prada, JL
- Guerrero, JMGD
- Martinez, OJ
- Garcia, J
- Alcaraz, B
- Jimeno, A
- Poveda, E
- Pernas, B
- Mena, A
- Grandal, M
- Castro, A
- Pedreira, JD
- Munoz, J
- Zubero, MZ
- Baraia-Etxaburu, JM
- Ibarra, S
- Ferrero, O
- de Munain, JL
- Camara, MM
- Lopez, I
- de la Pena, M
- Galera, C
- Albendin, H
- Iborra, A
- Moreno, A
- Campillo, MA
- Vidal, A
- Amador, C
- Pasquau, F
- Ena, J
- Benito, C
- Fenoll, V
- Suarez-Garcia, I
- Malmierca, E
- Gonzalez-Ruano, P
- Rodrigo, DM
- Mohamed-Balghata, MO
- Vidal, MAG
- de Zarraga, MA
- Perez, VE
- Molina, MJT
- Garcia, JV
- Carrera, EPC
- Gorgolas, M
- Cabello, A
- Alvarez, B
- Prieto, L
- Moreno, JS
- Caso, AA
- Prieto, JD
- Garcia, EC
- Puerto, MJG
- Vilalta, RF
- Ribera, AF
- Cohort Spanish HIV Res Network Co
Grupos
Abstract
Introduction: Our aims were to investigate the adherence to national guidelines of initial antiretroviral therapy (ART) in the Spanish multicenter CoRIS cohort during the years 2010-2015, to identify the reasons for the prescription of nonrecommended treatments, and to explore the role of institutional constraints to guideline compliance. Methods: ART regimens were classified as recommended, alternative or nonrecommended according to the guidelines. Physicians were asked the reasons for prescribing nonrecommended regimens. Factors associated with the prescription of non recommended regimens were assessed using multivariable logistic regression. Results: During the study period, 586 (10.7%) of 5479 patients who started ART were given a regimen not recommended in the guidelines. The most frequent reasons for prescribing nonrecommended regimens were: enrolment in clinical trials (43.3%), comorbidities and/or interactions (10.2%), pregnancy (8.7%), and cost (7.7%). Among 37 participating centers, 16 (43%), treating 3561 patients, reported limitations related with the cost of ART, and 20 (54%), treating 1365 patients, reported restrictions for prescribing at least one recommended antiretroviral. In multivariable analysis, a higher risk of receiving nonrecommended regimens was associated with male gender, HIV acquisition by heterosexual transmission, low viral loads, initiation of treatment during the years 2011 to 2015, and initiation of treatment in a center with restricted access to at least one antiretroviral drug. Conclusions: Compliance to clinical guidelines was high. A high proportion of centres reported cost limitations for ART or restricted access to at least one recommended antiretroviral drug, with a significant impact on the choice of initial regimens. (C) 2019 Elsevier Espafia, S.L.U. and Sociedad Espaliola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0213-005X, 1578-1852
- Tipo:
- Article
- Páginas:
- 580-587
- PubMed:
- 30982676
- Factor de Impacto:
- 0,317 SCImago ℠
- Cuartil:
- Q3 SCImago ℠
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA EDICIONES DOYMA S A
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- Cohort studies; Highly active antiretroviral therapy; Practice guidelines
Cita
Gonzalez J,Jarrin I,del Amo J,Navarro ML,Gonzalez MI,Blanco JL,Sobrino P,Hernando V,Alejos B,Alvarez D,Jarrin I,Sanz N,Moreno C,Munoz MA,Garcia I,Rico CG,de la Fuente JG,Torre AG,PORTILLA J,Merino E,REUS S,Boix V,Giner L,Gadea C,Portilla I,Pampliega M,Diez M,Rodriguez JC,Sanchez J,Gomez JL,Hernandez J,Aleman MR,Alonso MD,Hernandez MI,Diaz F,GARCIA D,Pelazas R,Lirola AL,Asensi V,Valle E,Carton JA,Carmenado M,Rubio R,Pulido F,Bisbal O,Hernando A,Lagarde M,Matarranz M,Dominguez L,Bermejo L,Santacreu M,Iribarren JA,Arrizabalaga J,Aramburu MJ,Camino X,Rodriguez F,von MA,Tome LP,Goenaga MA,Bustinduy MJ,Galparsoro HA,Ibarguren M,Umerez M,Gutierrez F,MASIA M,Padilla S,Navarro A,Montolio F,Robledano C,Colome JG,Adsuar A,Pascual R,Fernandez M,Garcia E,Garcia JA,Barber X,Muga R,Tor J,Sanvisens A,BERENGUER J,de Quiros JCLB,Miralles P,Gutierrez I,RAMIREZ M,Padilla B,Gijon P,Carrero A,Aldamiz T,Tejerina F,Parras FJ,Balsalobre P,Diez C,Vidal F,Peraire J,Vilades C,Veloso S,Vargas M,Lopez M,Olona M,Rull A,Rodriguez E,Alba V,MONTERO M,LÓPEZ J,BLANES M,TASIAS M,CASTRO I,CALABUIG E,CUÉLLAR S,SALAVERT M,FERNÁNDEZ JA,Gonzalez J,Arnalich F,Arribas JR,Bernardino JI,Castro JM,Escosa L,Herranz P,Hontanon V,Garcia S,Lopez MG,Gonzalez A,Martin ML,Mayoral M,Mellado MJ,Mican R,Montejano R,Montes ML,Moreno V,Perez I,Rodes B,Sainz T,Sendagorta E,Stella NC,Valencia E,Blanco JR,Oteo JA,Lbarra V,Metola L,SANZ MÁ,Perez L,PASCUAL A,Ramos C,Arazo P,Gil D,Dalmau D,Jaen A,Sanmarti M,Cairo M,Martinez J,Velli P,Font R,Xercavins M,ALONSO N,Rivero M,Reparaz J,de Alda MGR,Irigoyen C,Arraiza MJ,Segura F,Amengual MJ,Navarro G,Sala M,Cervantes M,Pineda V,SEGURA V,NAVARRO M,Anton E,Nogueras MM,de los Santos I,Sanz JS,Aparicio AS,Cepeda CS,Fraile LGF,Moreno S,Casado JL,Dronda F,MORENO A,Elias MJP,Ayerbe CG,Gutierrez C,Madrid N,Terron SD,MARTI P,Ansa U,Serrano S,Vivancos MJ,CANO A,BERNAL E,MUÑOZ A,Garcia F,Hernandez J,Pena A,Munoz L,Perez AB,Alvarez M,Chueca N,Vinuesa D,FERNANDEZ JA,Del Romero J,Rodriguez C,Puerta T,Carrio JC,VERA M,Ballesteros J,Antela A,Losada E,Riera M,Penaranda M,Leyes M,Ribas MA,Campins AA,VIDAL C,Fanjul F,Murillas J,Homar F,Santos J,Marquez M,Viciana I,Palacios R,PEREZ I,Gonzalez CM,Viciana P,Espinosa N,Lopez LF,Podzamczer D,Ferrer E,Imaz A,Tiraboschi J,Silva A,Saumoy M,Ribera E,Olalla J,del Arco A,de la Torre J,Prada JL,Guerrero JMGD,Martinez OJ,VERA FJ,MARTINEZ L,Garcia J,Alcaraz B,Jimeno A,Poveda E,Pernas B,Mena A,Grandal M,Castro A,Pedreira JD,Munoz J,Zubero MZ,Baraia JM,Ibarra S,Ferrero O,de Munain JL,Camara MM,Lopez I,de la Pena M,Galera C,Albendin H,PÉREZ A,Iborra A,Moreno A,Campillo MA,Vidal A,Amador C,Pasquau F,Ena J,Benito C,Fenoll V,Suarez I,Malmierca E,Gonzalez P,Rodrigo DM,Mohamed MO,Vidal M,de Zarraga MA,Perez VE,Molina MJT,Garcia JV,Carrera E,Gorgolas M,Cabello A,Alvarez B,Prieto L,Moreno JS,Caso AA,Prieto JD,Garcia EC,Puerto MJG,Vilalta RF,Ribera AF,Cohort Spanish HIV Res Network CO. Reasons for noncompliance with the national guidelines for initial antiretroviral therapy of HIV-infected patients in Spain, 2010-2015. Enferm. Infec. Microbiol. Clin. 2019. 37. (9):p. 580-587. IF:1,654. (4).