Portal de investigación
One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Brannstrom M
- Bokstrom H
- Dahm-Kahler P
- Ekberg J
- Enskog A
- Hagberg H
- Johannesson L
- Kvarnstrom N
- Molne J
- Olausson M
- Olofsson JI
- Rodriguez-Wallberg K
Grupos
Abstract
Objective: To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. Design: Part of an observational study. Setting: University teaching hospital. Patient(s): Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. Intervention(s): In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. Main Outcome Measure(s): Results of IVF-ET, parameters of pregnancy/birth, and surgical data of transplantation/cesarean section/hysterectomy. Result(s): Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal-vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 3 years after UTx. Conclusion(s): This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. (C) 2016 by American Society for Reproductive Medicine.
Datos de la publicación
- ISSN/ISSNe:
- 0015-0282, 1556-5653
- Tipo:
- Article
- Páginas:
- 261-266
- PubMed:
- 27125227
- Factor de Impacto:
- 2,237 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
FERTILITY AND STERILITY ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 112
Documentos
- No hay documentos
Filiaciones
Keywords
- Human; infertility; pregnancy; transplantation; uterus
Campos de Estudio
Cita
Brannstrom M,Bokstrom H,Dahm P,DIAZ C,Ekberg J,Enskog A,Hagberg H,Johannesson L,Kvarnstrom N,Molne J,Olausson M,Olofsson JI,Rodriguez K. One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation. Fertil. Steril. 2016. 106. (2):p. 261-266. IF:4,447. (1).