MONITORING PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS USING ULTRASOUND MORPHO-TEXTURAL MUSCLE BIOMARKERS: A PILOT STUDY

Fecha de publicación: 01/01/2018

Autores de IIS La Fe

Juan Francisco Vázquez Costa

Autor

Participantes ajenos a IIS La Fe

Martinez-Paya, JJ
Rios-Diaz, J
Medina-Mirapeix, F
del Bano-Aledo, ME

Grupos

Patología Neuromuscular y Ataxias

Abstract

The need is increasing for progression biomarkers that allow the loss of motor neurons in amyotrophic lateral sclerosis (ALS) to be monitored in clinical trials. In this prospective longitudinal study, muscle thickness, echointensity, echovariation and gray level co-occurrence matrix textural features are examined as possible progression ultrasound biomarkers in ALS patients during a 5-mo follow-up period. We subjected 13 patients to 3 measurements for 20 wk. They showed a significant loss of muscle, an evident tendency to loss of thickness and increased echointensity and echovariation. In regard to textural parameters, muscle heterogeneity tended to increase as a result of the neoformation of non-contractile tissue through denervation. Considering some limitations of the study, the quantitative muscle ultrasound biomarkers evaluated showed a promising ability to monitor patients affected by ALS. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

Datos de la publicación

ISSN/ISSNe:: 0301-5629, 1879-291X
Tipo:: Article
Páginas:: 102-109
DOI:: 10.1016/j.ultrasmedbio.2017.09.013
PubMed:: 29100791
Factor de Impacto:: 0,932 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Filiaciones

Martinez-Paya, JJ:: ECOFISTEM Research Group, Health Sciences Department, Facultad de Ciencias de la Salud, Universidad Catolica de Murcia, Guadalupe (Murcia), Spain

Univ Catolica Murcia, Fac Ciencias Salud, Hlth Sci Dept, ECOFISTEM Res Grp, Guadalupe, Murcia, Spain
Rios-Diaz, J:: Centro Universitario de Ciencias de la Salud San Rafael-Nebrija, Paseo de la Habana, Madrid, Spain

Fundacion San Juan de Dios, Madrid, Spain

Ctr Univ Ciencias Salud San Rafael Nebrija, Madrid, Spain

Fdn San Juan de Dios, Madrid, Spain
Medina-Mirapeix, F:: Physiotherapy Department, Facultad de Medicina, Universidad de Murcia, Spain

Univ Murcia, Fac Med, Physiotherapy Dept, Murcia, Spain
Vazquez-Costa, JF:: Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain

Instituto de Investigación. Neuromuscular and Ataxias Research Unit, Instituto de Investigacion Sanitaria la Fe (IIS La Fe), Valencia, Spain

Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Spain

Hosp Univ & Politecn La Fe, Dept Neurol, Valencia, Spain

Instituto de Investigación. IIS La Fe, Neuromuscular & Ataxias Res Unit, Valencia, Spain

Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid, Spain
del Bano-Aledo, ME:: Physiotherapy Department, Facultad de Medicina, Universidad de Murcia, Spain

Univ Murcia, Fac Med, Physiotherapy Dept, Murcia, Spain

Keywords

Amyotrophic lateral sclerosis; Motor neuron disease; Neuromuscular diseases; Biomarkers; Ultrasonography; Disease progression; Image processing computer-assisted

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