Invasive yeast infections in severely burned patients

Autores de IIS La Fe

• Ana Isabel Renau Escrig

  Autor

• Miguel Salavert Lletí

  Autor

Participantes ajenos a IIS La Fe

• Garcia-Vidal, C

Grupos

• Infección Grave

Abstract

Currently, there are few studies on candidaemia in the severely burned patient. These patients share the same risk factors for invasive fungal infections as other critically ill patients, but have certain characteristics that make them particularly susceptible. These include the loss of skin barrier due to extensive burns, fungal colonisation of the latter, and the use of hydrotherapy or other topical therapies (occasionally with antimicrobials). In addition, the increased survival rate achieved in recent decades in critically burned patients due to the advances in treatment has led to the increase of invasive Candida infections. This explains the growing interest in making an earlier and more accurate diagnosis, as well as more effective treatments to reduce morbidity and mortality of candidaemia in severe burned patients. A review is presented on all aspects of the burned patient, including the predisposition and risk factors for invasive candidiasis, pathogenesis of candidaemia, underlying immunodeficiency, local epidemiology and antifungal susceptibility, evolution and prognostic factors, as well as other non-Candida yeast infections. Finally, we include specific data on our local experience in the management of candidaemia in severe burned patients, which may serve to quantify the problem, place it in context, and offer a realistic perspective. (C) 2016 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.

Keywords

• Candidiasis; Candidaemia; Burned patients; Severe thermal injury; Vascular catheter; Mortality