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Nuclear cataract as an early predictive factor for recalcitrant juvenile idiopathic arthritis-associated uveitis

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Suelves, AM
  • Lamba, N
  • Meese, HK
  • Foster, CS
  • Gonzalez-Martin, JM
  • Christen, WG

Abstract

PURPOSE To analyze factors predictive of having treatment-resistant uveitis in patients with juvenile idiopathic arthritis (JIA) associated uveitis. METHODS The medical records of patients diagnosed with JIA-associated uveitis treated at a single tertiary referral center from October 2005 to March 2013 were reviewed retrospectively. The main outcome measures were demographic characteristics, ocular comorbidity, clinical course, treatments, and baseline risk factors associated with poor response to first-line therapies. RESULTS A total of 96 patients (175 eyes) were included. Of these, 58 patients (108 eyes) required biologic disease-modifying antirheumatic drugs or alkylating agents for their uveitis during follow-up (recalcitrant group), and 38 patients (67 eyes) did not (nonrecalcitrant group). Eyes of the recalcitrant group tended to have a higher incidence of cataract at baseline (49%; P < 0.0001). In the nonrecalcitrant group, the most frequent complications were cataract (20.9%) and secondary glaucoma (20.9%). The mean number of flares in the recalcitrant group was significantly reduced from 3.7/eye/year prior to cataract surgery to 1.6/eye/year after (P < 0.0001). Nuclear cataract was found to be an independent predictor for a severe course of JIA-associated uveitis. Any other type of cataract, posterior synechiae, male sex, or active uveitis at baseline were not found to be independently associated with recalcitrant uveitis. CONCLUSIONS Nuclear cataract at baseline evaluation is a risk factor for poor response to first-line therapies in JIA-associated uveitis patients.

Datos de la publicación

ISSN/ISSNe:
1091-8531, 1528-3933

JOURNAL OF AAPOS  MOSBY-ELSEVIER

Tipo:
Article
Páginas:
232-238
Factor de Impacto:
0,673 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 1

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