Portal de investigación
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Stucki, D
- Brites, D
- Jeljeli, L
- Coscolla, M
- Liu, QY
- Trauner, A
- Fenner, L
- Rutaihwa, L
- Borrell, S
- Luo, T
- Gao, Q
- Kato-Maeda, M
- Ballif, M
- Egger, M
- Macedo, R
- Mardassi, H
- Moreno, M
- Vilanova, GT
- Fyfe, J
- Globan, M
- Thomas, J
- Jamieson, F
- Guthrie, JL
- Asante-Poku, A
- Yeboah-Manu, D
- Wampande, E
- Ssengooba, W
- Joloba, M
- Boom, WH
- Basu, I
- Bower, J
- Saraiva, M
- Vasconcellos, SEG
- Suffys, P
- Koch, A
- Wilkinson, R
- Gail-Bekker, L
- Malla, B
- Ley, SD
- Beck, HP
- de Jong, BC
- Toit, K
- Sanchez-Padilla, E
- Bonnet, M
- Frank, M
- Beng, VNP
- Eisenach, K
- Alani, I
- Ndung'u, PW
- Revathi, G
- Gehre, F
- Akter, S
- Ntoumi, F
- Stewart-Isherwood, L
- Ntinginya, NE
- Rachow, A
- Hoelscher, M
- Cirillo, DM
- Skenders, G
- Hoffner, S
- Bakonyte, D
- Stakenas, P
- Diel, R
- Crudu, V
- Moldovan, O
- Al-Hajoj, S
- Otero, L
- Barletta, F
- Carter, EJ
- Diero, L
- Supply, P
- Comas, I
- Niemann, S
- Gagneux, S
Grupos
Abstract
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
Datos de la publicación
- ISSN/ISSNe:
- 1061-4036, 1546-1718
- Tipo:
- Article
- Páginas:
- 1535-1543
- DOI:
- 10.1038/ng.3704
- PubMed:
- 27798628
- Factor de Impacto:
- 21,979 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
NATURE GENETICS NATURE PORTFOLIO
Citas Recibidas en Web of Science: 316
Documentos
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Filiaciones
Cita
Stucki D,Brites D,Jeljeli L,Coscolla M,Liu QY,Trauner A,Fenner L,Rutaihwa L,Borrell S,Luo T,Gao Q,Kato M,Ballif M,Egger M,Macedo R,Mardassi H,Moreno M,Vilanova GT,Fyfe J,Globan M,Thomas J,Jamieson F,Guthrie JL,Asante A,Yeboah D,Wampande E,Ssengooba W,Joloba M,Boom WH,Basu I,Bower J,Saraiva M,Vasconcellos S,Suffys P,Koch A,Wilkinson R,Gail L,Malla B,Ley SD,Beck HP,de Jong BC,Toit K,Sanchez E,Bonnet M,GIL A,Frank M,Beng VNP,Eisenach K,Alani I,Ndung'u PW,Revathi G,Gehre F,Akter S,Ntoumi F,Stewart L,Ntinginya NE,Rachow A,Hoelscher M,Cirillo DM,Skenders G,Hoffner S,Bakonyte D,Stakenas P,Diel R,Crudu V,Moldovan O,Al S,Otero L,Barletta F,Carter EJ,Diero L,Supply P,Comas I,Niemann S,Gagneux S. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. Nat. Genet. 2016. 48. (12):p. 1535-1543. IF:27,959. (1).