Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders

Fecha de publicación: 01/08/2018

Autores de IIS La Fe

Sonia Herraiz Raya

Autor
Mónica Romeu Villarroya

Autor
Ana Buigues Lafuente

Autor
Vicenta Susana Martínez Cuenca

Autor
Inés Gómez Seguí

Autor
Joaquina Martinez Bonete

Autor
Nuria Pellicer De Castellvi

Autor
Antonio Pellicer Martínez

Autor

Participantes ajenos a IIS La Fe

Diaz-Garcia, C

Grupos

Hematología y Hemoterapia

Investigador Principal

Javier De La Rubia Comos
Medicina Reproductiva

Investigador Principal

José Morales Roselló

Abstract

Objective: To evaluate effects of autologous stem cell ovarian transplant (ASCOT) on ovarian reserve and IVF outcomes of women who arc poor responders with very poor prognosis. Design: Prospective observational pilot study. Setting: University hospital. Patient(s): Seventeen women who are poor responders. Intervention(s): Ovarian infusion of bone marrow-derived stem cells. Main Outcome Measure(s): Serum antimullerian hormone levels and antral follicular count (AFC), punctured follicles, and oocytes retrieved after stimulation (controlled ovarian stimulation) were measred. Apheresis was analyzed for growth factor concentrations. Result(s): The ASCOT resulted in a significant improvement in AFC 2 weeks after treatment. With an increase in AFC of three or more follicles and/or two consecutive increases in antimullerian hormone levels as success criteria, ovarian function improved in 81.3% of women. These positive effects were associated with the presence of fibroblast growth factor-2 and thrombospondin. During controlled ovarian stimulation, ASCOT increased the number of stimulable antral follicles and oocytes, but the embryo euploidy rate was low (16.1%). Five pregnancies were achieved: two after ET, three by natural conception. Conclusion(s): Our results suggest that ASCOT optimized the mobilization and growth of existing follicles, possibly related to fibroblast growth factor-2 and thrombospondin-1 within apheresis. The ASCOT improved follicle and oocyte quantity enabling pregnancy in women who are poor responders previously limited to oocyte donation. (C) 2018 by American Society for Reproductive Medicine.

Datos de la publicación

ISSN/ISSNe:: 0015-0282, 1556-5653
Tipo:: Article
Páginas:: 496-496
DOI:: 10.1016/j.fertnstert.2018.04.025
Factor de Impacto:: 2,332 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Herraiz, S:: La Fe Univ Hosp, Fdn IVI, Valencia, Spain

La Fe Univ Hosp, IVI RMA Valencia, Valencia, Spain

Instituto de Investigación. La Fe Univ Hosp, IIS La Fe, Reprod Med Res Grp, Valencia, Spain
Romeu, M:: Instituto de Investigación. La Fe Univ Hosp, IIS La Fe, Reprod Med Res Grp, Valencia, Spain

La Fe Univ Hosp, Womens Hlth Area, Valencia, Spain
Buigues, A:: La Fe Univ Hosp, Fdn IVI, Valencia, Spain

Instituto de Investigación. La Fe Univ Hosp, IIS La Fe, Reprod Med Res Grp, Valencia, Spain

Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia, Spain
Martinez, S:: La Fe Univ Hosp, Womens Hlth Area, Valencia, Spain
Diaz-Garcia, C:: IVI RMA London, London, England
Gomez-Segui, I:: La Fe Univ Hosp, Dept Hematol, Valencia, Spain
Martinez, J:: La Fe Univ Hosp, Dept Radiol, Valencia, Spain
Pellicer, N:: La Fe Univ Hosp, Womens Hlth Area, Valencia, Spain
Pellicer, A:: La Fe Univ Hosp, Fdn IVI, Valencia, Spain

Instituto de Investigación. La Fe Univ Hosp, IIS La Fe, Reprod Med Res Grp, Valencia, Spain

IVI RMA Rome, Rome, Italy