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Adverse effects of the renal accumulation of haem proteins. Novel therapeutic approaches

Data de publicació:

Autors de IIS La Fe

Autors aliens a IIS La Fe

  • Guerrero-Hue, M
  • Rubio-Navarro, A
  • Sevillano, A
  • Yuste, C
  • Gutierrez, E
  • Palomino-Antolin, A
  • Praga, M
  • Egido, J
  • Moreno, JA

Abstract

Haemoglobin and myoglobin are haem proteins that play a key role as they help transport oxygen around the body. However, because of their chemical structure, these molecules can exert harmful effects when they are released massively into the bloodstream, as reported in certain pathological conditions associated with rhabdomyolysis or intravascular haemolysis. Once in the plasma, these haem proteins can be filtered and can accumulate in the kidney, where they become cytotoxic, particularly for the tubular epithelium, inducing acute kidney failure and chronic kidney disease. In this review, we will analyse the different pathological contexts that lead to the renal accumulation of these haem proteins, their relation to both acute and chronic loss of renal function, the pathophysiological mechanisms that cause adverse effects and the defence systems that counteract such actions. Finally, we will describe the different treatments currently used and present new therapeutic options based on the identification of new cellular and molecular targets, with particular emphasis on the numerous clinical trials that are currently ongoing. (C) 2017 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.

Dades de la publicació

ISSN/ISSNe:
0211-6995, 1989-2284

NEFROLOGIA  SOC ESPANOLA NEFROLOGIA DR RAFAEL MATESANZ

Tipus:
Review
Pàgines:
13-26
PubMed:
28668175
Factor d'Impacte:
0,323 SCImago ℠
Quartil:
Q3 SCImago ℠

Cites Rebudes en Web of Science: 10

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Keywords

  • Haemoglobin; Myoglobin; Haemoglobinuria; Rhabdomyolysis; Haematuria; Acute kidney failure; Chronic kidney disease

Projectes associats

DIAGNÓSTICO GENÉTICO MOLECULAR DE LAS CILIOPATÍAS RENALES MEDIANTE SECUENCIACIÓN MASIVA DE NUEVA GENERACIÓN (NGS).

Investigador Principal: MARIA JOSE APARISI NAVARRO

GV/2016/057 . 2016

REGISTRO NACIONAL DE RECHAZO HUMORAL: ESTUDIO EPIDEMIOLOGICO MULTICENTRICO OBSERVACIONAL PROSPECTIVO PARA EVALUAR LAS CARACTERISTICAS CLINICAS, SEROLOGICAS E HISTOLOGICAS Y LA EVOLUCION A 5 AÑOS DEL RECHAZO HUMORAL POST-TRASPLANTE RENAL EN ESPAÑA

Investigador Principal: ISABEL BENEYTO CASTELLO

HUMORAL-KTX . 2011

UN ESTUDIO OBSERVACIONAL, NO INTERVENCIONISTA, MULTICÉNTRICO Y MULTINACIONAL DE PACIENTES CON SÍNDROME HEMOLÍTICO URÉMICO ATÍPICO (REGISTRO DE SHUA).

Investigador Principal: ELENA ROMÁN ORTIZ

ALE-ECU-2012-01 . 2013

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