18 F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with polymyalgia rheumatica: Screening for vasculitis.

Autores de IIS La Fe

• Karla Romelia Arevalo Ruales

  Autor

• Rosa Negueroles Albuixech

  Autor

• Jose Luis Loaiza Gongora

  Autor

• Elena Grau García

  Autor

• José Ivorra Cortés

  Autor

• 

  José Andrés Román Ivorra

  Autor

Grupos

• Reumatología

Abstract

OBJECTIVE: Polymyalgia rheumatica (PR) can be associated with large vessel vasculitis (LVV). We evaluate the diagnostic role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and its impact on the treatment of LVV associated with PR. MATERIALS AND METHODS: Retrospective study of patients diagnosed with PR. Data was collected from health records. Blood analysis included acute-phase reactants (APR), C-reactive protein (CRP) and erythrocyte sedimentation rate. An (18)F-FDG PET/CT scan was performed in those patients whose symptoms persisted, in those with elevated APR, those who required higher doses of steroids or those who had atypical features of PR (low-grade fever, weight loss, among others). RESULTS: Twenty-three were eligible; 48% (n = 11) of the patients were diagnosed with LVV associated with PR. The site was heterogeneous, but mostly involved the aorta. In 80% of the patients with LVV, a disease-modifying antirheumatic drug was added to their treatment. Elevated CRP values were associated with the likelihood of presenting LVV. CONCLUSIONS: LVV is not uncommon, clinical features and elevated CRP levels should raise suspicion of LVV associated with PR. (18)F-FDG PET/CT is useful in identifying LVV associated with PR.

Keywords

• Polimialgia reumatica; Polymyalgia rheumatica; Positron emission tomography - computed tomography; Tomografia por emision de positrones - tomografia computarizada; Vasculitis