Portal de investigación
Risk factors, survival, and impact of prophylaxis length in cytomegalovirus-seropositive lung transplant recipients: A prospective, observational, multicenter study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Monforte, V
- Sintes, H
- Lopez-Gallo, C
- Delgado, M
- Santos, F
- Zurbano, F
- Gavalda, J
- Maria Borro, Jose
- Redel-Montero, J
- Manuel Cifrian, Jose
- Roman, A
- Ussetti, P
Grupos
Abstract
Background: The optimal length of cytomegalovirus (CMV) prophylaxis in lung transplantation according to CMV serostatus is not well established. Methods: We have performed a prospective, observational, multicenter study to determine the incidence of CMV infection and disease in 92 CMV-seropositive lung transplant recipients (LTR), their related outcomes and risk factors, and the impact of prophylaxis length. Results: At 18 months post transplantation, 37 patients (40%) developed CMV infection (23 [25%]) or disease (14 [15.2%]). Overall mortality was higher in patients with CMV disease (64.3% vs 10.2%; P<.001), but only one patient died from CMV disease. In the multivariate analysis, CMV disease was an independent death risk factor (odds ratio [OR] 18.214, 95% confidence interval [CI] 4.120-80.527; P<.001). CMV disease incidence was higher in patients with 90-day prophylaxis than in those with 180-day prophylaxis (31.3% vs 11.8%; P=.049). Prophylaxis length was an independent risk factor for CMV disease (OR 4.974, 95% CI 1.231-20.094; P=.024). Sixteen patients withdrew from prophylaxis because of adverse events. Conclusion: CMV infection and disease in CMV-seropositive LTR remain frequent despite current prophylaxis. CMV disease increases mortality, whereas 180-day prophylaxis reduces the incidence of CMV disease.
Datos de la publicación
- ISSN/ISSNe:
- 1398-2273, 1399-3062
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1111/tid.12694
- PubMed:
- 28294487
- Factor de Impacto:
- 0,882 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
TRANSPLANT INFECTIOUS DISEASE WILEY
Citas Recibidas en Web of Science: 20
Documentos
- No hay documentos
Filiaciones
Keywords
- cytomegalovirus; ganciclovir; lung transplantation; prophylaxis; valganciclovir
Cita
Monforte V,Sintes H,Lopez C,Delgado M,Santos F,Zurbano F,SOLE A,Gavalda J,Maria J,Redel J,Manuel J,PASTOR A,Roman A,Ussetti P. Risk factors, survival, and impact of prophylaxis length in cytomegalovirus-seropositive lung transplant recipients: A prospective, observational, multicenter study. Transpl. Infect. Dis. 2017. 19. (3):UNSP e12694. IF:1,869. (3).