1. Inici
  2. Publicacions
  3. Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology

Data de publicació:

Autors de IIS La Fe

Autors aliens a IIS La Fe

  • Garrido-Gomez, T
  • Dominguez, F
  • Quiñonero A
  • Diaz-Gimeno, P
  • Kapidzic, M
  • Gormley, M
  • Ona, K
  • McMaster, M
  • Genbacev, O
  • Fisher, SJ
  • Simon, C

Grups d'Investigació

Abstract

In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with control cells, they failed to decidualize in vitro as demonstrated by morphological criteria and the analysis of stage-specific antigens (i.e., IGFBP1, PRL). These results were bolstered by global transcriptional profiling data that showed they were transcriptionally inert. Additionally, we used laser microdissection to isolate the decidua from tissue sections of the maternal-fetal interface in sPE. Global transcriptional profiling revealed defects in gene expression. Also, decidual cells from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in culture. Conditioned medium from these cells failed to support CTB invasion. To mimic aspects of the uterine environment in normal pregnancy, we added PRL and IGFBP1, which enhanced invasion. These data suggested that failed decidualization is an important contributor to down-regulated CTB invasion in sPE. Future studies will be aimed at determining whether this discovery has translational potential with regard to assessing a woman's risk of developing this pregnancy complication.

Dades de la publicació

ISSN/ISSNe:
0027-8424, 1091-6490

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  NATL ACAD SCIENCES

Tipus:
Article
Pàgines:
8468-8477
PubMed:
28923940
Factor d'Impacte:
6,092 SCImago ℠
Quartil:
Q1 SCImago ℠

Cites Rebudes en Web of Science: 192

Documents

  • No hi ha documents

Mètriques

Filiacions mostrar / ocultar

Keywords

  • preeclampsia; human endometrial stromal cells; decidua; cytotrophoblast; transcriptomics

Campos d'Estudi

Projectes associats

APLICACION DE TECNICAS LAPLACIANAS PARA LA MONITORIZACION DE LA ACTIVIDAD ELECTRICA DEL MUSCULO LISO HUMANO:ENFASIS EN ELECTROHISTEROGRAMA (LAMOHIS)

Investigador Principal: ALFREDO JOSÉ PERALES MARÍN

LAMOHIS PLAN NACIONAL I+D+I 2008-2011 . 2010

CON-CIENCIA-YV: PILDORAS DE SALUD

FCT-13-7457_FECYT_2013 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013

PAPEL DEL FACTOR DE CRECIMIENTO PLACENTARIO EN EL MANEJO DE LA PREECLAMPSIA NO SEVERA: ESTUDIO ALEATORIZADO

Investigador Principal: ALFREDO JOSÉ PERALES MARÍN

PI15/01935 . INSTITUTO DE SALUD CARLOS III . 2016

ESTUDIO PROSPECTIVO, DE SEGUIMIENTO, DE NIÑOS DE 23 A 25 MESES, NACIDOS DE MADRES QUE RECIBIERON CAPROATO DE HIDROXIPROGESTERONA INYECTABLE, 250 MG/ML O VEHICULO, PARA LA PREVENCION DEL PARTO PREMATURO.

Investigador Principal: ALFREDO JOSÉ PERALES MARÍN

17P-FU-004 . 2012

DETERMINACION DE LA TIROSIN-KINASA 1 SOLUBLE FMS-LIKE (SFLT-1) Y DEL FACTOR DE CRECIMIENTO PLACENTARIO (PIGF) COMO POSIBLES MARCADORES PARA EL DIAGNOSTICO PRECOZ Y PRONOSTICO DE LA PREECLAMPSIA.

Investigador Principal: ALFREDO JOSÉ PERALES MARÍN

SFLT-1/PIGF . 2010

Compartir la publicació