Haemodialysis significantly reduces serum levetiracetam levels inducing epileptic seizures: Case report

Autores de IIS La Fe

• María José Company Albir

  Autor

• Jesús Ruiz Ramos

  Autor

• María Remedios Marques Miñana

  Autor

• Carlos Vicent Perales

  Autor

• José Luis Poveda Andrés

  Autor

Participantes ajenos a IIS La Fe

• Solana Altabella A

Grupos

• Farmacogenética

  Investigador Principal

  María José Herrero Cervera

• Medicina Intensiva

  Leader

  Álvaro Castellanos Ortega

Abstract

What is known and objectiveLevetiracetam is used in the treatment of some forms of epilepsy. In renal impairment and patients on chronic haemodialysis, dose adjustment is required. We report a case. Case descriptionThis case report describes a woman on levetiracetam treatment who presented with generalized tonic-clonic seizures during a haemodialysis session. We report on treatment adjustment and on the impact of dialysis on levetiracetam levels. What is new and conclusionHaemodialysis reduces serum levetiracetam concentration and can lead to subtherapeutic levels. Close monitoring is necessary when dialysis is used on patients receiving anticonvulsant drugs that are extensively eliminated by the procedure.

Keywords

• dialysis; epilepsy; haemodialysis; levetiracetam; monitoring; pharmacokinetics; seizures