1. Inicio
  2. Publicaciones
  3. Direct oral anticoagulants in patients with hypertrophic cardiomyopathy and atrial fibrillation

Direct oral anticoagulants in patients with hypertrophic cardiomyopathy and atrial fibrillation

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Dominguez, F
  • Climent, V
  • Ripoll-Vera, T
  • Salazar-Mendiguchia, J
  • Garcia-Pinilla, JM
  • Urbano-Moral, JA
  • Fernandez-Fernandez, X
  • Lopez-Cuenca, D
  • Ajo-Ferrer, R
  • Sanz-Sanchez, J
  • Gomez-Perez, Y
  • Lopez-Garrido, MA
  • Barriales-Villa, R
  • Gimeno, JR
  • Garcia-Pavia, P

Grupos

Abstract

Background: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to describe the pattern of use, thromboembolic events, bleeding and quality of life in patients with HCM and AF treated with NOACs. Methods: Data from patients treated with NOACs (n = 99) and VKA (n = 433) at 9 inherited cardiac diseases units were retrospectively collected. Annual rates of embolic events, serious bleeding and death were analysed and compared. Quality of life and treatment satisfaction were evaluated with SF-36 and SAFUCA questionnaires in 80 NOAC-treated and 57 VKA-treated patients. Results: After median follow-up of 63 months (IQR: 26-109), thromboembolic events (TIA/stroke and peripheral embolism) occurred in 10% of patients on oral anticoagulation. Major/clinically relevant bleeding occurred in 3.8% and the global mortality rate was 23.3%. Thromboembolic event rate was 0.62 per 100 patient-years in the NOAC group vs. 1.59 in the VKA group [subhazard ratio (SHR) 0.32;95% CI: 0.04-2.45; p = 0.27]. Major/clinically relevant bleeding occurred in 0.62 per 100 person-years in the NOAC group vs. 0.60 in the VKA group (SHR 1.28;95% CI 0.18-9.30; p = 0.85). Quality of life scores were similar in both groups; however, NOAC-treated patients achieved higher scores in the SAFUCA. Conclusions: HCM patients with AF on NOACs showed similar embolic and bleeding rates to those on VKA. Although quality of life was similar in both groups, the NOAC group reported higher treatment satisfaction. (C) 2017 Elsevier B.V. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0167-5273, 1874-1754

INTERNATIONAL JOURNAL OF CARDIOLOGY  ELSEVIER IRELAND LTD

Tipo:
Article
Páginas:
232-238
Factor de Impacto:
1,200 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 34

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Hypertrophic cardiomyopathy; Atrial fibrillation; Anticoagulation

Campos de estudio

Proyectos asociados

RED INVESTIGACION (RECAVA)

RD06/0014/0004 . INSTITUTO DE SALUD CARLOS III; FUNDACION PARA LA INV BIOMEDICA- HOSPITAL GREGORIO MARAÑON; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2006

CANALOPATIAS EN LA ATIOPATOGENIA DEL SINDROME DE MUERTE SUBITA DEL LACTANTE

Investigador Principal: ESTHER ZORIO GRIMA

PI07/0831 . INSTITUTO DE SALUD CARLOS III . 2007

RED DE BIOBANCOS (BIOBANCOS)

RD09/0076/00021 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

ESTUDIO DE MICRORNAS IMPLICADOS EN LOS SISTEMAS HEMOSTÁTICO, PROTEOLÍTICO Y ANGIOGÉNICO: SU RELACIÓN CON LA TROMBOSIS Y LA PATOLOGÍA ENDOMETRIAL.

PROMETEO/2011/027 . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; CONSELLERIA DE EDUCACION . 2011

RED CARDIOVASCULAR

Investigador Principal: FRANCISCO ESPAÑA FURIO

RD12/0042/0029 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013

CARACTERIZACION METABOLOMICA DE LA MIOCARDIOPATIA ARRITMOGENICA

Investigador Principal: ESTHER ZORIO GRIMA

2013_0126_CRC_METABOLOMICA_ZORIO . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013

CARACTERIZACIÓN DEL PATRÓN DE MICRORNAS EN LA MUERTE SÚBITA CARDIACA DE ORIGEN ISQUÉMICO. ANÁLISIS DE SU RELACIÓN CON LA DISLIPEMIA, LA GRASA EPICÁRDICA, LA ESTEATOSIS NO ALCOHÓLICA Y FACTORES DE COAGULACION Y FIBRINOLISIS.

Investigador Principal: ESTHER ZORIO GRIMA

2013_0454_CRC_ZORIO . ASTRAZENECA FARMACÉUTICA SPAIN, S.A.; FUNDACION ESPAÑOLA DE TROMBOSIS Y HEMOSTASIA . 2014

MECANISMOS DE ENFERMEDAD EN LA MIOCARDIOPATIA ARRITMOGENICA, MEJORAS EN SU DIAGNOSTICO Y BUSQUEDA DE DIANAS TERAPEUTICAS.

Investigador Principal: ESTHER ZORIO GRIMA

PI14/01477 . INSTITUTO DE SALUD CARLOS III . 2015

Cita

Compartir