Portal de investigación
Protein S100 beta in Late-Pregnancy Fetuses with Low Birth Weight and Abnormal Cerebroplacental Ratio
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Khalil, A
- Alba-Redondo, A
- Martinez-Triguero, L
- Akhoundova, F
- Perales-Marin, A
- Thilaganathan, B
Grupos
Abstract
Objective: To evaluate the umbilical cord venous 510013 levels in late-pregnancy fetuses with abnormal growth and cerebral redistribution. Methods: The pulsatility index of the umbilical and middle cerebral arteries and the cerebroplacental ratio (CPR) were measured in 132 fetuses at >= 34 weeks, and the CPR was converted into multiples of the median (MoM). A blood sample from the umbilical vein was collected at birth, and the umbilical venous 510013 levels were evaluated in small and non-small for gestational age (SGA) fetuses, with and without abnormal Doppler indices. The levels of 510013 were correlated with birth weight (BW) centile, CPR MoM and cord venous pH. Results: While CPR MoM correlated with BW centile, S100 beta showed no correlation with any of the studied fetal parameters. In addition, no differences were observed in S100 beta level according to BW centile or Doppler parameters, neither was there any difference between SGA with low CPR MoM and non-SGA with normal CPR MoM. Conclusion: Late-pregnancy fetuses with abnormal growth or cerebral redistribution have normal cord blood levels of S100 beta at birth. In these fetuses, the potential consequences of chronic hypoxemia on the fetal brain might not be detectable using tissue necrosis markers. (C) 2016 S. Karger AG, Basel
Datos de la publicación
- ISSN/ISSNe:
- 1015-3837, 1421-9964
- Tipo:
- Article
- Páginas:
- 15-22
- DOI:
- 10.1159/000445114
- PubMed:
- 27104871
- Factor de Impacto:
- 1,183 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
FETAL DIAGNOSIS AND THERAPY KARGER
Citas Recibidas en Web of Science: 6
Documentos
- No hay documentos
Filiaciones
Keywords
- S100 beta; Fetal growth restriction; Fetal Doppler ultrasound; Small for gestational age; Late-onset fetal growth restriction; Brain tissue damage
Proyectos y Estudios Clínicos
RED DE SALUD MATERNO INFANTIL Y DEL DESARROLLO
Investigador Principal: MÁXIMO VENTO TORRES
RD12/0026/0012 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013
PAPEL DEL FACTOR DE CRECIMIENTO PLACENTARIO EN EL MANEJO DE LA PREECLAMPSIA NO SEVERA: ESTUDIO ALEATORIZADO
Investigador Principal: ALFREDO JOSÉ PERALES MARÍN
PI15/01935 . INSTITUTO DE SALUD CARLOS III . 2016
Cita
MORALES J,Khalil A,Alba A,Martinez L,Akhoundova F,Perales A,Thilaganathan B. Protein S100 beta in Late-Pregnancy Fetuses with Low Birth Weight and Abnormal Cerebroplacental Ratio. Fetal Diagn Ther. 2017. 41. (1):p. 15-22. IF:1,813. (3).