Basic and Clinical Approaches for Fertility Preservation and Restoration in Cancer Patients

Autores de IIS La Fe

• Jose Vicente Medrano Plaza

  Autor

• María Del Mar Andrés Moreno

  Autor

• Sofia Clara Garcia Williams

  Autor

• Sonia Herraiz Raya

  Autor

• Teresa Vilanova Perez

  Autor

• Antonio Pellicer Martínez

  Autor

Participantes ajenos a IIS La Fe

• Goossens, E

Grupos

• Investigación Clínica y Traslacional en Cáncer

• Medicina Fetal y Reproductiva

Abstract

As gonadotoxic adverse effects of antineoplastic treatments can result in infertility, gamete cryopreservation is routinely offered to patients as the strategy to preserve their fertility. However, there are many cases where gold standards cannot be applied, as is the case for prepubertal cancer patients and others unable to produce gametes or their precursors at the moment of diagnosis. With an increasing number of cancer survivors in our society, strategies using either cryopreserved gonadal tissue or stem cells have been developed to allow cancer survivors to achieve fatherhood, and recent advances in the field have increased public interest. In this review, we discuss the latest updates in fertility preservation from a basic and a clinical point of view.

Keywords

• *fertility preservation; *germ cell transplantation; *in vitro differentiation; *in vitro maturation; *ovarian cortex cryopreservation; *testicular tissue grafting