Portal de investigación
Multilocus microsatellite analysis of European and African Candida glabrata isolates
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Chillemi V
- Lo Passo C
- van Diepeningen AD
- Rharmitt S
- Delfino D
- Cascio A
- Nnadi NE
- Cilo BD
- Sampaio P
- Tietz HJ
- Criseo G
- Romeo O
- Scordino F
Grupos
Abstract
This study aimed to elucidate the genetic relatedness and epidemiology of 127 clinical and environmental Candida glabrata isolates from Europe and Africa using multilocus microsatellite analysis. Each isolate was first identified using phenotypic and molecular methods and subsequently, six unlinked microsatellite loci were analyzed using automated fluorescent genotyping. Genetic relationships were estimated using the minimum-spanning tree (MStree) method. Microsatellite analyses revealed the existence of 47 different genotypes. The fungal population showed an irregular distribution owing to the over-representation of genetically different infectious haplotypes. The most common genotype was MG-9, which was frequently found in both European and African isolates. In conclusion, the data reported here emphasize the role of specific C. glabrata genotypes in human infections for at least some decades and highlight the widespread distribution of some isolates, which seem to be more able to cause disease than others.
Datos de la publicación
- ISSN/ISSNe:
- 0934-9723, 1435-4373
- Tipo:
- Article
- Páginas:
- 885-892
- Factor de Impacto:
- 1,331 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES SPRINGER
Citas Recibidas en Web of Science: 10
Documentos
- No hay documentos
Filiaciones
Proyectos asociados
FUNGEMIA: EPIDEMIOLOGIA, MECANISMOS DE RESISTENCIA ANTIFUNGICA Y TIPADO MOLECULAR
090/2006- EVES - PEMAN . 2006
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Investigador Principal: EMILIA CANTON LACASA
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ESTUDIO EPIDEMIOLOGICO DE DIAGNOSTICO PRECOZ DE LA CANDIDIASIS INVASORA EN PACIENTES NEONATOS PRETERMINO DE MUY BAJO PESO. ESTUDIO CANDI-NEO
Investigador Principal: MÁXIMO VENTO TORRES
AST-MYC-2010-01
ESTUDIO OBSERVACIONAL, PROSPECTIVO Y MULTICÉNTRICO EN CUIDADOS INTENSIVOS PARA EVALUAR LA FIABILIDAD DIAGNÓSTICOA DE LA PCR (REACCIÓN EN CADENA DE LA POLIMERASA) EN PACIENTES EN TRATAMIENTO ANTIFÚNGICO EMPÍRICO POR SOSPECHA DE CANDIDIASIS INVASIVA. (ESTUD IO MICAFEM).
Investigador Principal: PAULA RAMÍREZ GALLEYMORE
AST-INF-2012-01
Cita
Chillemi V,Lo Passo C,van AD,Rharmitt S,Delfino D,Cascio A,Nnadi NE,Cilo BD,Sampaio P,Tietz HJ,Pemán J,Criseo G,Romeo O,Scordino F. Multilocus microsatellite analysis of European and African Candida glabrata isolates. Eur J Clin Microbiol Infect Dis. 2016. 35. (6):p. 885-892. IF:2,727. (2).