Effects of diazoxide in multiple sclerosis: A randomized, double-blind phase 2 clinical trial.

Fecha de publicación: 01/10/2015

Autores de IIS La Fe

Bonaventura Casanova Estruch

Autor
Diana Muñoz Gómez

Autor

Participantes ajenos a IIS La Fe

Villoslada P
Rovira A
Montalban X
Arroyo R
Paul F
Meca-Lallana V
Ramo C
Fernandez O
Saiz A
Garcia-Merino A
Ramió-Torrentà L
Oreja-Guevara C
Martinez-Rodriguez JE
Lensch E
Prieto JM
Meuth SG
Nuñez X
Campás C
Pugliese M
NeuroAdvan study

Grupos

Abstract

OBJECTIVE: The aim of this study was to test the safety of diazoxide and to search for signs of efficacy in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: In this multicenter, randomized, placebo-controlled, double-blind trial (treatment allocation was concealed), 102 patients with RRMS were randomized to receive a daily oral dose of diazoxide (0.3 and 4 mg/d) or placebo for 24 weeks (NCT01428726). The primary endpoint was the cumulative number of new T1 gadolinium-enhancing lesions per patient, recorded every 4 weeks from week 4 to week 24. Secondary endpoints included brain MRI variables such as the number of new/enlarging T2 lesions and the percentage brain volume change (PBVC); clinical variables such as the percentage of relapse-free patients, relapse rate, and change in the Expanded Disability Status Scale score; and safety and tolerability. RESULTS: Diazoxide was well-tolerated and it produced no serious adverse events other than 1 case of Hashimoto disease. At the 2 doses tested, diazoxide did not improve the primary endpoint or the MRI and clinical variables related to the presence of new lesions or relapses. Patients treated with diazoxide showed reduced PBVC compared with the placebo group, although such changes could be confounded by the higher disease activity of the treated group and the vascular effects of diazoxide. CONCLUSION: At the doses tested, oral diazoxide did not decrease the appearance of new lesions evident by MRI. The effects in slowing the progression of brain atrophy require further validation. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that for patients with RRMS, diazoxide (0.3 and 4 mg/d) does not significantly change the number of new MRI T1 gadolinium-enhancing lesions.

Datos de la publicación

ISSN/ISSNe:: 2332-7812, 2332-7812
Tipo:: Article
Páginas:: -
DOI:: 10.1212/NXI.0000000000000147
Factor de Impacto:: 0,839 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Métricas

Filiaciones

Villoslada P:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Rovira A:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Montalban X:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Arroyo R:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Paul F:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Meca-Lallana V:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Ramo C:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Fernandez O:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Saiz A:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Garcia-Merino A:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Ramió-Torrentà L:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Casanova B:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Oreja-Guevara C:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Muñoz D:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Martinez-Rodriguez JE:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Lensch E:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Prieto JM:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Meuth SG:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Nuñez X:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Campás C:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain
Pugliese M:: Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic (P.V., A.S.), Barcelona, Spain

Unitat de RM (Servei de Radiologia) (A.R., X.M.), Departamento de Neurología-Neuroinmunología, Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Vall d'Hebron, Barcelona, Spain

Hospital Clinico San Carlos (R.A., C.O.-G.), Madrid, Spain

NeuroCure Clinical Research Center and Department of Neurology (F.P.), Charité University Medicine Berlin, Berlin, Germany

Hospital de La Princesa (V.M.-L.), Madrid, Spain

Hospital Germans Trias i Pujol (C.R.), Badalona, Spain

Hospital Regional Universitario (IBIMA) (O.F.), Malaga, Spain

Hospital Puerta de Hierro (A.G.-M.), Madrid, Spain

Hospital Universitari Dr Josep Trueta (L.R.-T.), IDIBGI, Girona, Spain

Hospital La Fe (B.C.), Valencia, Spain

Hospital Xeral-Cies (D.M.), Vigo, Spain

Hospital del Mar (J.E.M.-R.), Barcelona, Spain

Deutsche Klinik für Diagnostik (E.L.), Wiesbaden, Germany

Hospital Universitario Santiago de Compostela (J.M.P.), Spain

Department of Neurology (S.G.M.), University of Munster, Germany

TrialFormSupport (X.N.), Barcelona, Spain

Advancell, Advanced In Vitro Cell Technologies, S.A (C.C.), Barcelona, Spain

and Neurotec Pharma S.L (M.P.), Barcelona, Spain

Proyectos asociados

PROYECTO CAIBER

CAI08/01/0061 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2009

RED DE BIOBANCOS (BIOBANCOS)

RD09/0076/00021 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

PATRONES DE RM CEREBRAL Y MEDULAR EN RELACION CON LA PRESENCIA DE AUTOANTIGENOS NEURONALES RECONOCIDOS POR INMUNOGLOBULINAS M PRESENTES EN EL LIQUIDO CEFALORRAQUIDEO DE PACIENTES DE ESCLEROSIS MULTIPLE.

Investigador Principal: ISABEL BOSCÁ BLASCO

MERCK SERONO DR. CASANOVA . ALMIRALL S.A; FUNDACIÓN BIOGEN IDEC; MERCK S.L.U; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010