microRNAs expression in endometriosis and their relation to angiogenic factors.

Autores de IIS La Fe

• Luis Andres Ramon Nuñez

  Autor

• 

  Aitana Braza Boils

  Autor

• Juan Gilabert Estelles

  Autor

• Francisco España Furio

  Autor

• Melitina Chirivella Casanova

  Autor

• Amparo Estelles Cortes

  Autor

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

Endometriosis is a common, multifactorial disease in which angiogenesis may be involved in the growth of endometrium outside the uterus. microRNAs (miRNAs) are 21-22 nucleotide non-coding RNAs that regulate gene expression and play fundamental roles in biological processes. The objective of this study was to analyze several miRNAs related to angiogenesis and the angiogenic factors, vascular endothelial growth factor-A (VEGF-A) and thrombospondin-1 (TSP-1), in endometriotic lesions (ovarian endometrioma, peritoneal lesion and rectovaginal nodule) and eutopic endometrium from women with endometriosis.