Myocardial and peripheral lymphocytic transcriptomic dissociation of beta-adrenoceptors and G protein-coupled receptor kinases in heart transplantation.

Autores de IIS La Fe

• Jaume Agüero Ramón-Llin

  Autor

• Luis Almenar Bonet

  Autor

• Pilar D'ocon Navaza

  Autor

• Joaquín Rueda Soriano

  Autor

• Diana Vicente Miralles

  Autor

• 

  Luis Vicente Martínez Dolz

  Autor

• Antonio Salvador Sanz

  Autor

Participantes ajenos a IIS La Fe

• Oliver E
• Montó F

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

The genetic expression of adrenergic receptors plays an important pathophysiologic role in heart failure. G protein-coupled receptor kinases (GRKs) desensitize the beta-receptor to catecholaminergic stimulation. It has been suggested that their mRNA expression in peripheral lymphocytes could mirror the changes in their myocardial expression in the failing heart, but this relationship between the myocyte and lymphocyte has not been studied in heart transplantation (HT). The objective of this study was to analyze adrenergic receptor and GRK mRNA expression in myocardium and lymphocytes and their correlation.