Fetal cerebral and umbilical Doppler in pregnancies complicated by late-onset placental abruption

Autores de IIS La Fe

• 

  José Morales Roselló

  Autor

• José Alberola Rubio

  Autor

• David Hervás Marín

  Autor

• Victoria Fornés Ferrer

  Autor

• Asuncion Perales Marin

  Autor

Participantes ajenos a IIS La Fe

• Khalil, A
• Akhoundova, F
• Salvi, S
• Morlando, M
• Sivanathan, J
• Thilaganathan, B

Grupos

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Objective: To evaluate whether changes in the cerebroplacental Doppler and birth weight (BW) suggestive of chronic fetal hypoxemia, precede the development of late-onset placental abruption (PA) after 32 weeks.Methods: In a multicenter retrospective study, the Doppler examinations of the fetal umbilical artery (UA) and middle cerebral artery (MCA) recorded after 32 weeks were collected in pregnancies subsequently developing PA. The BW centiles were calculated and the MCA pulsatility indices (PI), and UA PI were converted into multiples of the median (MoM). Afterwards, a comparison was made with a group of fetuses, which did not develop PA. Logistic regression was used to adjust for potential confounders and evaluate the feasibility of the prediction model.Results: Pregnancies complicated by late-onset PA (n=31) presented lower MCA PI (p=0.015) and were smaller (p<0.001) than those who did not (n=1294). Logistic regression analysis indicated that cerebral vasodilation was more important than umbilical flow in the explanation of PA (MCA PI OR=0.106, p=0.014 and UA PI OR 1.901, p=0.32). In addition, the influence of BW exerted was residual (BW centile OR=0.989, p=0.15).Conclusions: Fetuses developing late-onset PA demonstrate significant cerebral vasodilation with scarce placental dysfunction, suggesting the existence of some kind of chronic hypoxemia that follows the late-onset pattern.

Keywords

• Fetal middle cerebral artery Doppler; umbilical artery Doppler; placental abruption; late-onset fetal growth restriction