Primary paraesophageal Ewing's sarcoma: an uncommon case report and literature review

Autores de IIS La Fe

• Jose Alejandro Perez Fidalgo

  Autor

• Amparo Sempere Talens

  Autor

• Silvia Navarro Rosales

  Autor

Participantes ajenos a IIS La Fe

• Tarazona N
• Navarro L
• Cejalvo JM
• Gambardella V
• Cervantes A

Grupos

• Hematología y Hemoterapia

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

Ewing's sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing's sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The patient was totally refractory to chemotherapy and died 17 months after diagnosis. We underscore the need for better understanding of the molecular pathogenesis of the disease and improved systemic therapy options.

Keywords

• Ewing's sarcoma; recurrence; immunohistochemistry; fusion genes