Avances en el tratamiento de la hepatitis C.

Autores de IIS La Fe

• Carmen Vinaixa Aunés

  Autor

• Victoria Aguilera Sancho-Tello

  Autor

• 

  Marina Berenguer Haym

  Autor

Grupos

• Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

Abstract

Recent approval of new protease inhibitors (boceprevir and telaprevir) for the treatment of chronic hepatitis C, genotype 1, has meant a significant increase in the sustained viral response both in naive and previously treated patients. However, such efficacy increase has been accompanied by an increase in adverse events, sometimes serious, and new practical issues including different approaches to stop treatment and drug interactions that recommend a close follow-up of patients. The efficacy and safety of triple therapy in special populations such as cirrhotic and transplanted patients is less known and has some particulars, meaning that its administration requires an exhaustive monitoring.

Keywords

• Boceprevir, Hepatitis C, Inhibidores de la proteasa, Interferón pegilado, Pegylated interferon, Protease inhibitors, Ribavirina, Ribavirine, Telaprevir