Portal de investigación
Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Beltrán-Pavez C.
- Gutiérrez-López M.
- Rubio-Garrido M.
- Valadés-Alcaraz A.
- Ramos J.T.
- Jiménez De Ory S.
- Navarro M.
- Díez-Romero C.
- Pulido F.
- Holguín Á.
- Mellado M.J.
- Escosa L.
- García Hortelano M.
- Sainz T.
- González-Tomé M.I.
- Rojo P.
- Blázquez D.
- Prieto-Tato L.
- Epalza C.
- Guillén S.
- Navarro M.L.
- Saavedra J.
- Santos M.
- Santiago B.
- Aguilera-Alonso D.
- Carrasco I.
- Roa M.Á.
- Penín M.
- Martínez J.
- Badillo K.
- Oñate E.
- Pocheville I.
- Garrote E.
- Colino E.
- Gómez Sirvent J.
- Garzón M.
- Román V.
- Angulo R.
- Neth O.
- Falcón L.
- Terol P.
- Santos J.L.
- Moreno D.
- Lendínez F.
- Peromingo E.
- Uberos J.
- Ruiz B.
- Grande A.
- Romero F.J.
- Pérez C.
- Lillo M.
- Losada B.
- Herranz M.
- Bustillo M.
- Collado P.
- Couceiro J.A.
- Vila L.
- Calviño C.
- Oltra M.
- Gavilán C.
- Montesinos E.
- Dapena M.
- Álvarez C.
- Jiménez B.
- Andrés A.G.
- Marugán V.
- Ochoa C.
- Alfayate S.
- Menasalvas A.I.
- Ruiz Del Prado Y.
- Soler-Palacín P.
- Frick M.A.
- Mur A.
- López N.
- Méndez M.
- Mayol L.
- Vallmanya T.
- Calavia O.
- García L.
- Coll M.T.
- Pineda V.
- Rius N.
- Dueñas J.
- Fortuny C.
- Noguera-Julián A.
- Bernardino I.
- Montes M.L.
- Valencia E.
- Rubio R.
- Bisbal O.
- Gaspar Alonso G.
- Berenguer J.
- Díez C.
- Aldamiz T.
- Montilla P.
- Bermúdez E.
- Valerio M.
- Arponen S.
- Gimeno A.
- Cervero M.
- Torres R.
- Moreno S.
- Pérez M.ªJ.
- Ryan P.
- Troya J.
- Sanz J.
- Losa J.
- Gómez R.
- Iribarren J.A.
- Rodríguez F.
- Pascual L.
- Aramburu M.J.
- Goikoetxea A.J.
- Aguirrebengoa L.
- Muñoz J.
- Ibarra S.
- Hernández M.
- Gómez Sirvent J.L.
- Cárdenes M.Á.
- López-Cortés L.F.
- Roca C.
- Llaves S.
- Ríos M.J.
- Rodríguez J.
- Palomo V.
- Pasquau J.
- García C.
- Hernández J.
- Martínez C.
- Rivero A.
- Camacho Á.
- Merino D.
- Martínez E.
- Mateos F.
- Blanch J.J.
- Torralba M.
- Arazo P.
- Samperiz G.
- Crusells M.J.
- San Joaquín I.
- Miralles C.
- Ocampo A.
- Pousada G.
- Mena Á.
- Galindo M.J.
- Ferrando R.
- Portilla J.
- Portilla I.
- Gutiérrez F.
- Masiá M.
- Robledano C.
- Adsuar A.
- Hinojosa C.
- Bachiller P.
- Abadía J.
- Mostaza J.L.
- Pérez R.
- Galera C.
- Albendín H.
- Pérez A.
- Blanco J.R.
- Burgos J.
- Torres B.
- Lazzari E.
Grupos
Abstract
The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures. © 2020, The Author(s).
Datos de la publicación
- ISSN/ISSNe:
- 2045-2322, 2045-2322
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 33037235
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 1,240 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Scientific Reports NATURE PORTFOLIO
Documentos
- No hay documentos
Filiaciones
Keywords
- Adolescent; Adult; Anti-HIV Agents; Child; Child, Preschool; Cohort Studies; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Infant; Male; Mutation; Pediatrics; Spain; Viral Load; Young Adult; anti human immunodeficiency virus agent; adolescent; adult; antiviral resistance; child; cohort analysis; drug effect; female; genetics; genotype; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; infant; male; mutation; pediatrics; preschool child; Spain; virology; virus load; young adult
Campos de Estudio
Cita
Beltrán C,Gutiérrez M,Rubio M,Valadés A,Ramos JT,Jiménez De Ory S,Navarro M,Díez C,Pulido F,Holguín Á,Mellado MJ,Escosa L,García Hortelano M,Sainz T,González MI,Rojo P,Blázquez D,Prieto L,Epalza C,Guillén S,Navarro ML,Saavedra J,Santos M,Santiago B,Aguilera D,Carrasco I,Roa MÁ,Penín M,Martínez J,Badillo K,Oñate E,Pocheville I,Garrote E,Colino E,Gómez Sirvent J,Garzón M,Román V,Angulo R,Neth O,Falcón L,Terol P,Santos JL,Moreno D,Lendínez F,Peromingo E,Uberos J,Ruiz B,Grande A,Romero FJ,Pérez C,Lillo M,Losada B,Herranz M,Bustillo M,Collado P,Couceiro JA,Vila L,Calviño C,PIQUERAS AI,OLTRA M,Gavilán C,Montesinos E,Dapena M,Álvarez C,Jiménez B,Andrés AG,Marugán V,Ochoa C,Alfayate S,Menasalvas AI,Ruiz Y,Soler P,Frick MA,Mur A,López N,Méndez M,Mayol L,Vallmanya T,Calavia O,García L,Coll MT,Pineda V,Rius N,Dueñas J,Fortuny C,Noguera A,Bernardino I,Montes ML,Valencia E,Rubio R,Bisbal O,Gaspar Alonso G,Berenguer J,Díez C,Aldamiz T,Montilla P,Bermúdez E,Valerio M,Arponen S,Gimeno A,Cervero M,Torres R,Moreno S,Pérez MªJ,Ryan P,Troya J,Sanz J,Losa J,Gómez R,Iribarren JA,Rodríguez F,Pascual L,Aramburu MJ,Goikoetxea AJ,Aguirrebengoa L,Muñoz J,Ibarra S,Hernández M,Gómez Sirvent JL,Cárdenes MÁ,López LF,Roca C,Llaves S,Ríos MJ,Rodríguez J,Palomo V,Pasquau J,García C,Hernández J,Martínez C,Rivero A,Camacho Á,Merino D,Martínez E,Mateos F,Blanch JJ,Torralba M,Arazo P,Samperiz G,Crusells MJ,San Joaquín I,Miralles C,Ocampo A,Pousada G,Mena Á,MONTERO M,SALAVERT M,CUÉLLAR S,Galindo MJ,Ferrando R,Portilla J,Portilla I,Gutiérrez F,Masiá M,Robledano C,Adsuar A,Hinojosa C,Bachiller P,Abadía J,Mostaza JL,Pérez R,Galera C,Albendín H,Pérez A,Blanco JR,Burgos J,Torres B,Lazzari E. Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017). Sci. Rep. 2020. 10. (1):16891. IF:4,380. (1).