Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg)

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Nyssen O.P.
  • Vaira D.
  • Tepes B.
  • Kupcinskas L.
  • Bordin D.
  • Pérez-Aisa Á.
  • Gasbarrini A.
  • Castro-Fernández M.
  • Bujanda L.
  • Garre A.
  • Lucendo A.J.
  • Vologzhanina L.
  • Jurecic N.B.
  • Rodrigo-Sáez L.
  • Huguet J.M.
  • Voynovan I.
  • Perez-Lasala J.
  • Romero P.M.
  • Vujasinovic M.
  • Abdulkhakov R.
  • Barrio J.
  • Fernandez-Salazar L.
  • Mégraud F.
  • O'Morain C.
  • Gisbert J.P.
  • Ilchishina T.
  • Ariño I.
  • Zaytsev O.
  • Perona M.
  • Sarsenbaeva A.S.
  • Alekseenko S.
  • Dominguez-Cajal M.
  • Rodriguez B.J.G.
  • Notari P.A.
  • Pellicano R.
  • Consorci I.M.
  • Nardone G.
  • Bote J.M.B.-A.
  • Nuñez Ó.
  • Gomez-Camarero J.
  • Guadix J.H.
  • Fiorini G.
  • Jonaitis L.
  • Galán H.A.
  • Ferrer L.
  • Molina-Infante J.
  • Kikec Z.
  • Alcaide N.
  • Lanas A.
  • Sant'Orsola V.C.
  • Medina-Chulia E.
  • Canelles P.
  • Santos-Fernandez J.
  • Velayos B.
  • Lafuente M.R.
  • Moreno M.J.
  • Dekhnich N.N.
  • Varela P.
  • de la Coba C.
  • Osipenko M.F.
  • Lopez R.R.-Z.
  • Huerta-Madrigal A.
  • Livzan M.A.
  • Pozzati L.S.
  • Iyo E.
  • Amelchugova O.S.
  • Vasyutin A.V.
  • Tsukanov V.V.
  • Barenys M.
  • Burkov S.G.
  • Gravina A.G.
  • Romano M.
  • Bakulina N.V.
  • Fernandez-Bermejo M.
  • Alcedo J.
  • Franceschi F.
  • Campillo A.
  • Seruga M.
  • Villarroya R.P.
  • Mego M.
  • Dore M.P.
  • Tito L.
  • Gmez B.
  • Jimenez J.L.D.
  • Bermejo F.
  • Algaba A.
  • Belousova L.N.
  • Plotnikova E.Y.
  • Calvet X.
  • Figuerola A.
  • Tarasova L.
  • Grigorieva L.
  • Amorena E.
  • Estremera F.
  • Sánchez-Pobre P.
  • Millastre J.
  • Tomas A.
  • Baryshnikova N.
  • Kucheryavyy Y.A.
  • Kononova A.
  • Bakulin I.
  • Cerezo F.J.M.
  • Venciene R.
  • Zhestkova T.V.
  • Rocco A.

Grupos

Abstract

Background: Managing Helicobacter pylori infection requires constant decision making, and each decision is open to possible errors. Aim: The aim was to evaluate common mistakes in the eradication of H. pylori, based on the "European Registry on Helicobacter pylori management". Methods: European Registry on Helicobacter pylori management is an international multicentre prospective noninterventional registry evaluating the decisions and outcomes of H. pylori management by European gastroenterologists in routine clinical practice. Results: Countries recruiting more than 1000 patients were included (26,340 patients). The most common mistakes (percentages) were: (1) To use the standard triple therapy where it is ineffective (46%). (2) To prescribe eradication therapy for only 7 to 10 days (69%). (3) To use a low dose of proton pump inhibitors (48%). (4) In patients allergic to penicillin, to prescribe always a triple therapy with clarithromycin and metronidazole (38%). (5) To repeat certain antibiotics after eradication failure (>15%). (6) Failing to consider the importance of compliance with treatment (2%). (7) Not to check the eradication success (6%). Time-trend analyses showed progressive greater compliance with current clinical guidelines. Conclusion: The management of H. pylori infection by some European gastroenterologists is heterogeneous, frequently suboptimal and discrepant with current recommendations. Clinical practice is constantly adapting to updated recommendations, although this shift is delayed and slow. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0192-0790, 1539-2031

JOURNAL OF CLINICAL GASTROENTEROLOGY  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
98-108
PubMed:
33405435
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,929 SCImago ℠
Cuartil:
Q2 SCImago ℠

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Keywords

  • Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Prospective Studies; Proton Pump Inhibitors; Registries; amoxicillin; bismuth; bismuth citrate plus metronidazole plus tetracycline; bismuth salt; clarithromycin; levofloxacin; metronidazole; omeprazole; proton pump inhibitor; tetracycline; amoxicillin; antiinfective agent; clarithromycin; metronidazole; proton pump inhibitor; Article; clinical practice; disease registry; drug efficacy; eradication therapy; Europe; gastroenterologist; Helicobacter infection; human; low drug dose; medical error; patient compliance; practice guideline; prescription; prospective study; treatment failure; combination drug therapy; Helicobacter pylori; register

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