Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Djukovic A.
- Garzón M.J.
- Canlet C.
- Cabral V.
- Lalaoui R.
- García-Garcerá M.
- Rechenberger J.
- Tremblay-Franco M.
- Peñaranda I.
- Kuster B.
- Rolain J.-M.
- Debrauwer L.
- Xavier K.B.
- Xavier J.B.
- Ubeda C.
Grupos
Abstract
Infections by multidrug-resistant Enterobacteriaceae (MRE) are life-threatening to patients. The intestinal microbiome protects against MRE colonization, but antibiotics cause collateral damage to commensals and open the way to colonization and subsequent infection. Despite the significance of this problem, the specific commensals and mechanisms that restrict MRE colonization remain largely unknown. Here, by performing a multi-omic prospective study of hospitalized patients combined with mice experiments, we find that Lactobacillus is key, though not sufficient, to restrict MRE gut colonization. Lactobacillus rhamnosus and murinus increase the levels of Clostridiales bacteria, which induces a hostile environment for MRE growth through increased butyrate levels and reduced nutrient sources. This mechanism of colonization resistance, an interaction between Lactobacillus spp. and Clostridiales involving cooperation between microbiota members, is conserved in mice and patients. These results stress the importance of exploiting microbiome interactions for developing effective probiotics that prevent infections in hospitalized patients. © 2022, The Author(s).
Datos de la publicación
- ISSN/ISSNe:
- 2041-1723, 2041-1723
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 36153315
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 4,846 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Nature Communications NATURE PORTFOLIO
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Filiaciones
Keywords
- Animals; Anti-Bacterial Agents; Butyrates; Clostridiales; Enterobacteriaceae; Lactobacillus; Mice; Prospective Studies; ampicillin; butyric acid; neomycin; probiotic agent; vancomycin; antiinfective agent; butyric acid derivative; antibiotics; colonization; nutrient; probiotics; adult; animal experiment; antibiotic resistance; antibiotic therapy; Article; bacterial colonization; Clostridiales; comorbidity; comparative study; controlled study; Enterobacteriaceae; female; gastrointestinal tract; gene sequence; human; Lactobacillus; Lactobacillus murinus; Lactobacillus rhamnosus; metabolomics; mouse; multidrug resistant Enterobacteriaceae; nonhuman; nuclear magnetic resonance; animal; Clostridiales; prospective study
Campos de Estudio
Cita
Djukovic A,Garzón MJ,Canlet C,Cabral V,Lalaoui R,García M,Rechenberger J,Tremblay M,Peñaranda I,PUCHADES L,PINEDA A,GONZÁLEZ EM,SALAVERT M,LÓPEZ JL,SANZ MÁ,SANZ J,Kuster B,Rolain J-M,Debrauwer L,Xavier KB,Xavier JB,Ubeda C. Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae. Nat. Commun. 2022. 13. (1):5617. IF:16,600. (1).
Portal de investigación