Correction of iron deficiency anemia in liver transplantation. Preliminary study;

Autores de IIS La Fe

• Iratxe Zarragoikoetxea Jauregui

  Autor

• Andrea Boscà Robledo

  Autor

• Paula Carmona García

  Autor

Participantes ajenos a IIS La Fe

• Pérez L.
• Blasi A.
• Gutierrez R.
• Caballero M.
• Pérez J.
• Vidal J.
• Salvador P.
• Ojinaga G.
• Duque P.
• Colmenero J.
• Colomina M.J.
• Llaurado S.
• Sabate A.

Grupos

• Anestesia y Cuidados Críticos

• Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

• Medicina Perioperatoria, Anestesiología y Reanimación

Abstract

Context: In liver transplantation (LT), anemia and transfusion of blood products have a negative impact on morbidity and mortality. Methods: Multicenter, prospective observational study. The main objective was to assess whether correction of iron deficiency anemia with intravenous iron was feasible in LT candidates. Its efficacy and adverse effects were evaluated. Patients with Hb value < 115 g/l and ferritin values < 800 ng/ml were included. Based on the increase in Hb > 10 g/l compared to its baseline level, the analysis of 76 patients was considered. An anemia study was carried out, assigning to the study group those who met the criteria for iron deficiency anemia, which followed a protocol of administration of up to two doses of iron before LT. Results: Two hundred ninety-six LT were performed during the study period, 48% of patients had an Hb value < 115 g/l. Forty-three patients made up the study group, in 5 patients the first dose was not administered. The second dose was administered to 55% of patients. No patient presented serious adverse effects or alterations in liver function. Hemoglobin increased compared to baseline by a median of 11.22 g/l (6.47-15.97) after the first administration and 11.64 g/l (6.49-16.78) after the second. Conclusions: The implementation of patient blood management in LT through the administration of intravenous iron is effective and safe. It is necessary to routinely characterize and treat the presence of iron deficiency anemia in these patients. © 2025 Elsevier España, S.L.U.

Keywords

• Administration, Intravenous; Adult; Aged; Anemia, Iron-Deficiency; Female; Ferritins; Hemoglobins; Humans; Iron; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Prospective Studies; ferritin; iron; hemoglobin; iron; Article; blood transfusion; drug efficacy; drug safety; human; iron deficiency anemia; liver disease; liver function; liver transplantation; morbidity; mortality; multicenter study; observational study; adult; aged; blood; clinical trial; drug therapy; etiology; female; intravenous drug administration; male; middle aged; postoperative complication; prospective study