Prophylaxis with nebulized liposomal amphotericin B for Aspergillus infection in lung transplant patients does not cause changes in the lipid content of pulmonary surfactant.

Autores de IIS La Fe

• Amparo Solé Jover

  Autor

• Maria Del Carmen Bravo Laguna

  Autor

Participantes ajenos a IIS La Fe

• Monforte V
• López-Sánchez A
• Zurbano F
• Ussetti P
• Casals C
• Cifrian J
• de Pablos A
• Román A

Grupos

• Infección Grave

Abstract

Prophylaxis with inhaled liposomal amphotericin B has proven to be safe and effective for preventing infection due to Aspergillus spp in lung transplant recipients. However, the liposome contains a large quantity of phospholipids, and inhalation of these substances could potentially change the composition of pulmonary surfactant. The aim of this study was to determine the lipid composition of pulmonary surfactant in patients receiving inhaled liposomal amphotericin B prophylaxis.