Cerebral phaeohyphomycosis: Description of a case and review of the literature

Autores de IIS La Fe

• Juan Salvador Frasquet Artes

  Autor

• Javier Pemán García

  Autor

• Marino Blanes Juliá

  Autor

• Jose Luis Cano Muñoz

  Autor

• José Luis López Hontangas

  Autor

Participantes ajenos a IIS La Fe

• Hernández-Porto M
• Jiménez-Herrero E

Grupos

• Infección Grave

Abstract

Cerebral phaeohyphomycosis is a rare invasive fungal infection with very few cases referenced in the literature. There is no standardized treatment, and it is associated with poor outcomes. Cladophialophora bandana, a fungus with special tropism for the central nervous system, is one of the causal agents of phaeohyphomycosis. The case presented here deals with a brain abscess by C bantiana in an adult with Crohn's disease had beed being treated with immunosuppressive drugs. Despite the correct etiological diagnosis, surgical and pharmacological treatments, the patient died 32 days after surgery. A description of the case is followed by a review of all cerebral C. bandana phaeohyphomycosis cases published in the last 10 years. Regardless of the use of advanced new imaging techniques in the diagnosis and treatment with new antifungal agents, cerebral phaeohyphomycosis by C bandana continues to have very poor prognosis. While new more successful therapeutic treatments appear, a combined surgical and pharmacological approach seems to be more appropriate for this severe mycosis. (C) 2012 Revista lberoamericana de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.

Keywords

• Phaeohyphomycosis; Cladophialophora bantiana; Cerebral abscess