Microbiological procedures for the diagnosis, management, and study of invasive fungal infections

Autores de IIS La Fe

• Emilia Canton Lacasa

  Autor

• Julio Garcia Rodriguez

  Autor

• 

  Javier Pemán García

  Autor

Participantes ajenos a IIS La Fe

• Martín-Mazuelos E
• Guinea J

Grupos

• Infección Grave

  

  Investigador Principal

  María Ángeles Tormo Mas

Abstract

Invasive fungal infections (IFIs) are difficult to diagnose and cause a high mortality to an expanding spectrum of patients. Culture of clinical samples has limitations for the diagnosis of IFI and alternative procedures have been developed. Among them, serum determination of galactomannan or beta-1,3-d-glucan, and antimicelium and antimannan antibodies are relevant. The use of molecular procedures and mass spectrometry (MALDI-TOF) are encouraging tools for the optimization of the diagnosis and management of patients with IFI. The proposal of species-specific breakpoint to classify the isolates as resistant or susceptible to antifungal agents and the necessity of monitor the azole serum levels deserve greater attention. (C) 2013 Elsevier Espana, S.L. All rights reserved.

Keywords

• Invasive fungal Infection; Candida; Aspergillus; Diagnosis; Biomarkers; Antifungal agents; Azoles; Antifungal susceptibility; MALDI-TOF