Portal de investigación
Time from symptoms onset to remdesivir is associated with the risk of ICU admission: a multicentric analyses
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Alonso-Navarro, R
- Ramírez, M
- Masiá, M
- Paredes, R
- Montejano, R
- Povar-Echeverria, M
- Carratalà, J
- Bernal, E
- Dueñas, C
- Flores, J
- Fanjul, F
- Gutiérrez, I
- Rico, V
- Mateu, L
- Cadiñanos, J
- Berenguer, J
- Soriano, A
Grupos
Abstract
BackgroundShorter duration of symptoms before remdesivir has been associated with better outcomes. Our goal was to evaluate variables associated with the need of ICU admission in a cohort of hospitalized patients for COVID-19 under remdesivir including the period from symptoms onset to remdesivir.MethodsWe conducted a retrospective multicentric study analysing all patients admitted with COVID-19 in 9 Spanish hospitals who received treatment with remdesivir in October 2020. The main outcome was the need of ICU admission after 24 h of the first dose of remdesivir.ResultsIn our cohort of 497 patients, the median of days from symptom onset to remdesivir was 5 days, and 70 of them (14.1%) were later admitted into ICU. The clinical outcomes associated with ICU admission were days from symptoms onset (5 vs. 6; p = 0.023), clinical signs of severe disease (respiratory rate, neutrophil count, ferritin levels and very-high mortality rate in SEIMC-Score) and the use of corticosteroids and anti-inflammatory drugs before ICU. The only variable significatively associated with risk reduction in the Cox-regression analyses was <= 5 days from symptoms onset to RDV (HR: 0.54, CI95%: 0.31-0.92; p = 0.024).ConclusionFor patients admitted to the hospital with COVID-19, the prescription of remdesivir within 5 days from symptoms onset diminishes the need of ICU admission.
Datos de la publicación
- ISSN/ISSNe:
- 1471-2334, 1471-2334
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 37142994
- Factor de Impacto:
- 1,042 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
BMC INFECTIOUS DISEASES BMC
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- SARS-CoV-2; Remdesivir; Days from symptoms onset; ICU; Progression
Cita
Alonso R,Ramírez M,Masiá M,Paredes R,Montejano R,Povar M,Carratalà J,SALAVERT M,Bernal E,Dueñas C,Flores J,Fanjul F,Gutiérrez I,Rico V,Mateu L,Cadiñanos J,Berenguer J,Soriano A. Time from symptoms onset to remdesivir is associated with the risk of ICU admission: a multicentric analyses. BMC Infect. Dis. 2023. 23. (1):286. IF:3,400. (2).