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Associations between Non-Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Rucandio, I
  • Fernandez-Saavedra, R
  • Fernandez-Martinez, R
  • Conde-Vilda, E
  • Quejido, AJ

Grupos

Abstract

Previous studies have found inconsistent associations between heavy metals and metalloids (cadmium, lead, mercury, and arsenic), and reproductive outcomes. The biofluid concentrations of ten non-essential trace elements (Hg, Pb, As, Ba, Sr, Rb, Cs, Sn, Ni, and Co) were evaluated in 51 Spanish women undergoing ICSI, PGT-A, and SET/FET. Nine out of ten non-essential elements were detectable in follicular fluid, whole blood, and urine collected the day of vaginal oocyte retrieval (VOR) and the day of embryo transfer and then analyzed by ICP-MS or Tricell DMA-80 for mercury. Elevated mercury and strontium concentrations in follicular fluid were associated with poor ovarian response and preimplantation outcomes. Worst preimplantation outcomes were also identified in women with elevated whole-blood strontium or mercury, urinary arsenic, barium, and tin the day of VOR. High concentrations of urinary rubidium on VOR day were linked with enhanced fertilization and blastocyst development. Excessive titanium in whole blood was associated with lower odds of implantation, clinical pregnancy, and achieving a live birth in a given IVF cycle. Excessive urinary arsenic on the day of embryo transfer was associated with lower odds of live birth. Although these preliminary results need to be confirmed in larger populations, distinguishing organic and inorganic element forms, our findings show that some non-essential elements have a detrimental impact on human IVF outcomes.

Datos de la publicación

ISSN/ISSNe:
2039-4705, 2039-4713

Journal of Xenobiotics  MDPI

Tipo:
Article
Páginas:
1093-1108
PubMed:
39189177
Factor de Impacto:
0,157 SCImago ℠
Cuartil:
Q4 SCImago ℠

Citas Recibidas en Web of Science: 8

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Keywords

  • non-essential trace elements; IVF outcomes; ovarian response; biofluids; ICP-MS; Tricell DMA 80

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