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Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Izzy, M
  • Russo, FP
  • Kirchner, VA
  • Rammohan, A
  • Belli, LS
  • Polak, WG
  • Berg, T

Grupos

Abstract

Background Despite the WHO's report of 24 available SARS-CoV-2 vaccines, limited data exist regarding vaccination policies for liver transplant (LT) patients. To address this, we conducted a global multi-society survey (EASL-ESOT-ELITA-ILTS) in LT centers.Methods A digital questionnaire assessing vaccine policies, safety, efficacy, and center data was administered online to LT centers.Results Out of 168 responding centers, 46.4%, 28%, 13.1%, 10.7%, and 1.8% were from European, American, Western Pacific, Southeast Asian, and Eastern Mediterranean Regions. Most LT centers prioritized COVID-19 vaccine access for LT patients (76%) and healthcare workers (86%), while other categories had lower priority (30%). One-third of responders recommended mRNA vaccine exclusively, while booster doses were widely recommended (81%). One-third conducted post-vaccine liver function tests post COVID-19 vaccine. Only 16% of centers modified immunosuppression, and mycophenolate discontinuation or modification was the main approach. Side effects were seen in 1 in 1,000 vaccinated patients, with thromboembolism, acute rejection, and allergic reaction being the most severe. mRNA showed fewer side effects (-3.1, p = 0.002).Conclusion COVID-19 vaccines and booster doses were widely used among LT recipients and healthcare workers, without a specific vaccine preference. Preventative immunosuppression adjustment post-vaccination was uncommon. mRNA vaccines demonstrated a favorable safety profile in this population.

Datos de la publicación

ISSN/ISSNe:
2813-2440, 2813-2440

Frontiers in Transplantation  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
-
PubMed:
38993892

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Keywords

  • vaccine; SARS-CoV-2; liver; transplant; survey; policy; side effect; worldwide activity

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