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  3. Recompensation Following Alcohol-Related Hepatitis Is Associated With Increased Survival: Results From a Multicenter Study

Recompensation Following Alcohol-Related Hepatitis Is Associated With Increased Survival: Results From a Multicenter Study

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Gratacós-Ginès J.
  • Ruz-Zafra P.
  • Herms Q.
  • Celada-Sendino M.
  • Villagrasa A.
  • Cáceres F.
  • Martín-Mateos R.
  • Echavarría V.
  • Sánchez J.
  • Barreales M.
  • Tejedor-Tejada J.
  • Vázquez-Rodríguez S.
  • Cañete N.
  • Fernández-Carrillo C.
  • Valenzuela M.
  • Marti-Aguado D.
  • Horta D.
  • Quiñones M.
  • Bernal-Monterde V.
  • Acosta S.
  • Artaza T.
  • Pinazo J.
  • Villar-Lucas C.
  • Prieto De la Torre M.
  • Clemente-Sánchez A.
  • Badia-Aranda E.
  • Alventosa-Mateu C.
  • Giráldez-Gallego Á.
  • Rivera-Esteban J.
  • Solís-Muñoz P.
  • Alvarado-Tapias E.
  • Cabezas J.
  • Ventura-Cots M.
  • Fernández-Rodríguez C.
  • Rodríguez M.
  • Tomé S.
  • Caballería J.
  • Bataller R.
  • Pose E.
  • Ardèvol A.
  • Del Barrio M.
  • Fernández-Vázquez I.
  • Frisancho L.E.
  • García-Retortillo M.
  • Gómez-Medina C.
  • Jara L.
  • Maderuelo E.
  • Martí-Carretero A.
  • Morales D.
  • Barriga O.R.
  • Rodríguez-Perálvarez M.L.
  • Roget M.
  • Soriano G.
  • Villaverde J.

Grupos

Abstract

Background & Aims The rate of recompensation following alcohol-related hepatitis is unknown. The aims of this study were to assess the rate, predictors, and clinical impact of recompensation in survivors of alcohol-related hepatitis, and to develop adapted recompensation criteria. Methods Nationwide registry-based study including patients with alcohol-related hepatitis who were discharged between 2014 and 2021. Recompensation was defined according to: (1) Baveno VII criteria; or (2) expanded criteria for alcohol-related hepatitis in which alcohol abstinence was not required (alcohol-related hepatitis liberal-abstinence criteria); and was assessed at 1 and 3 years. A landmark analysis was used to evaluate the impact of recompensation on transplant-free survival. Results A total of 577 patients (85% with cirrhosis) were included. The rate of recompensation at 1 and 3 years was 9.9% and 8.8% (Baveno VII), and 11.4% and 14.3% (alcohol-related hepatitis liberal-abstinence). In patients with cirrhosis, rates were 8.2% and 9.0% at 1 and 3 years (Baveno VII). The absence of decompensation prior to alcohol-related hepatitis, higher baseline alkaline phosphatase levels and lower Child-Pugh score were independently associated with recompensation. In patients abstinent from alcohol at 1 year, the rate of recompensation at 1 and 3 years was 26.5% and 25.8%, respectively. Patients with recompensated disease had higher estimated 5-year transplant-free survival (84.9% vs 47.7% in decompensated disease; P log-rank < .001). Survival estimates did not differ when classifying patients according to alcohol-related hepatitis liberal-abstinence criteria. Recompensation after alcohol-related hepatitis was a predictor of long-term survival. Conclusions Recompensation in alcohol-related hepatitis is common, particularly following abstinence, and is associated with increased survival. Predicting recompensation in alcohol-related hepatitis can be valuable in decision-making, including the evaluation for liver transplantation. © 2026 American Gastroenterological Association Institute.

Datos de la publicación

ISSN/ISSNe:
1542-3565, 1542-7714

Clinical Gastroenterology and Hepatology  ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
-
PubMed:
42242660
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
2,691 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • Abstinence; Alcohol-Associated; Cirrhosis; Decompensation; Survival

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